RASSF1

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Ras association (RalGDS/AF-6) domain family 1
Identifiers
Symbol(s)	RASSF1; 123F2; NORE2A; RASSF1A; RDA32; REH3P21
External IDs	OMIM: 605082 HomoloGene: 10499
Gene ontology Molecular Function: • zinc ion binding • diacylglycerol binding • identical protein binding • metal ion binding Cellular Component: • nucleus • microtubule Biological Process: • cell cycle • cell cycle arrest • intracellular signaling cascade • Ras protein signal transduction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	11186	n/a
Ensembl	ENSG00000068028	n/a
Uniprot	Q9NS23	n/a
Refseq	NM_170715 (mRNA) NP_733833 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 3: 50.34 - 50.35 Mb	n/a
Pubmed search	[1]	n/a

Ras association (RalGDS/AF-6) domain family 1, also known as RASSF1, is a human gene.

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[1]

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