RASGRP3

From Wikipedia, the free encyclopedia

RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Identifiers

RASGRP3; GRP3; KIAA0846

External IDs

OMIM: 609531 MGI: 3028579 HomoloGene: 15019

Gene ontology
Molecular Function:	• signal transducer activity • Ras guanyl-nucleotide exchange factor activity • calcium ion binding • protein binding • zinc ion binding • Ras GTPase binding • diacylglycerol binding • Rap GTPase activator activity
Cellular Component:	• intracellular • cytoplasm • integral to plasma membrane
Biological Process:	• MAPKKK cascade • Ras protein signal transduction • regulation of GTPase activity • regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

n/a

Refseq

NM_170672 (mRNA)
NP_733772 (protein)

NM_207246 (mRNA)
NP_997129 (protein)

Location

Chr 2: 33.51 - 33.64 Mb

Chr 17: 75.37 - 75.43 Mb

Pubmed search

[1]

[2]

RAS guanyl releasing protein 3 (calcium and DAG-regulated), also known as RASGRP3, is a human gene.^[1]

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated).

[edit] Further reading

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Lorenzo PS, Kung JW, Bottorff DA, et al. (2001). "Phorbol esters modulate the Ras exchange factor RasGRP3.". Cancer Res. 61 (3): 943–9. PMID 11221888.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Teixeira C, Stang SL, Zheng Y, et al. (2003). "Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.". Blood 102 (4): 1414–20. doi:10.1182/blood-2002-11-3621. PMID 12730099.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brodie C, Steinhart R, Kazimirsky G, et al. (2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.". Mol. Pharmacol. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Aiba Y, Oh-hora M, Kiyonaka S, et al. (2004). "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16612–7. doi:10.1073/pnas.0407468101. PMID 15545601.
Roberts DM, Anderson AL, Hidaka M, et al. (2004). "A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.". Mol. Cell. Biol. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMID 15572660.
Zheng Y, Liu H, Coughlin J, et al. (2005). "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.". Blood 105 (9): 3648–54. doi:10.1182/blood-2004-10-3916. PMID 15657177.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Okamura SM, Oki-Idouchi CE, Lorenzo PS (2007). "The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain.". J. Biol. Chem. 281 (47): 36132–9. doi:10.1074/jbc.M605093200. PMID 17012239.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.