RASGRP2

From Wikipedia, the free encyclopedia

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

Identifiers

RASGRP2; CDC25L; CALDAG-GEFI

External IDs

OMIM: 605577 MGI: 1333849 HomoloGene: 4250

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity • calcium ion binding • kinase activity • diacylglycerol binding
Cellular Component:	• intracellular • cytosol • plasma membrane
Biological Process:	• regulation of cell growth • Ras protein signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005825 (mRNA)
NP_005816 (protein)

NM_011242 (mRNA)
NP_035372 (protein)

Location

Chr 11: 64.25 - 64.27 Mb

Chr 19: 6.4 - 6.42 Mb

Pubmed search

[1]

[2]

RAS guanyl releasing protein 2 (calcium and DAG-regulated), also known as RASGRP2, is a human gene.^[1]

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated).

[edit] Further reading

Kedra D, Seroussi E, Fransson I, et al. (1997). "The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13.". Hum. Genet. 100 (5-6): 611–9. PMID 9341881.
Kawasaki H, Springett GM, Toki S, et al. (1998). "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13278–83. PMID 9789079.
Clyde-Smith J, Silins G, Gartside M, et al. (2000). "Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.". J. Biol. Chem. 275 (41): 32260–7. doi:10.1074/jbc.M006087200. PMID 10918068.
Guo FF, Kumahara E, Saffen D (2001). "A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2.". J. Biol. Chem. 276 (27): 25568–81. doi:10.1074/jbc.M101277200. PMID 11292831.
Toki S, Kawasaki H, Tashiro N, et al. (2001). "Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons.". J. Comp. Neurol. 437 (4): 398–407. PMID 11503142.
Eto K, Murphy R, Kerrigan SW, et al. (2002). "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12819–24. doi:10.1073/pnas.202380099. PMID 12239348.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katagiri K, Shimonaka M, Kinashi T (2004). "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1.". J. Biol. Chem. 279 (12): 11875–81. doi:10.1074/jbc.M310717200. PMID 14702343.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.