RASGRP1

From Wikipedia, the free encyclopedia

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Identifiers

RASGRP1; CALDAG-GEFI; CALDAG-GEFII; MGC129998; MGC129999; RASGRP; V; hRasGRP1

External IDs

OMIM: 603962 MGI: 1314635 HomoloGene: 4195

Gene ontology
Molecular Function:	• Ras guanyl-nucleotide exchange factor activity • calcium ion binding • lipid binding
Cellular Component:	• intracellular • membrane fraction
Biological Process:	• Ras protein signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005739 (mRNA)
NP_005730 (protein)

NM_011246 (mRNA)
NP_035376 (protein)

Location

Chr 15: 36.57 - 36.64 Mb

Chr 2: 116.97 - 117.03 Mb

Pubmed search

[1]

[2]

Ras guanyl releasing protein 1 (calcium and DAG-regulated), also known as RASGRP1, is a human gene.^[1]

RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. The corresponding rat gene rbc7, which lacks a 5-prime exon, represents a 5-prime and 3-prime truncated version of a larger normal rat transcript that encodes a predicted 90-kD protein. This shorter transcript has not been found in humans.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated).

[edit] Further reading

Dower NA, Stang SL, Bottorff DA, Ebinu JO, Dickie P, Ostergaard HJ, Stone JC (2000). "RasGRP is essential for mouse thymocyte differentiation and TCR signaling.". Nature Immunology 1 (4): 317-21. PMID 11017103.
Priatel JJ, Teh SJ, Dower NA, Stone JC, et al. (2002). "RasGRP1 Transduces Low-Grade TCR Signals Which Are Critical For T Cell Development, Homeostasis and Differentiation.". Immunity 17 (5): 617-27. PMID 12433368.
Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS et al. (2007). "Chronic Immunodeficiency in Mice Lacking RasGRP1 Results in CD4 T Cell Immune Activation and Exhaustion.". J. Immunol. 179 (4): 2143-52. PMID 17675473.
Priatel JJ, Chen X, Dhanji S, Abraham N, et al. (2006). "RasGRP1 Transmits Pro-Differentiation TCR Signaling that is Crucial for CD4 T Cell Development.". J. Immunol. 177 (3): 1470-80. PMID 16849453.
Ebinu JO, Bottorff DA, Chan EY, et al. (1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.". Science 280 (5366): 1082-6. PMID 9582122.
Kawasaki H, Springett GM, Toki S, et al. (1998). "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13278-83. PMID 9789079.
Bottorff D, Ebinu J, Stone JC (1999). "RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.". Mamm. Genome 10 (4): 358-61. PMID 10087292.
Topham MK, Prescott SM (2001). "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.". J. Cell Biol. 152 (6): 1135-43. PMID 11257115.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bivona TG, Pérez De Castro I, Ahearn IM, et al. (2003). "Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.". Nature 424 (6949): 694-8. doi:10.1038/nature01806. PMID 12845332.
Madani S, Hichami A, Cherkaoui-Malki M, et al. (2004). "Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation.". J. Biol. Chem. 279 (2): 1176-83. doi:10.1074/jbc.M306252200. PMID 14583629.
Klinger MB, Guilbault B, Goulding RE, Kay RJ (2005). "Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.". Oncogene 24 (16): 2695-704. doi:10.1038/sj.onc.1208334. PMID 15829980.
Liu Y, Zhu M, Nishida K, et al. (2007). "An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.". J. Exp. Med. 204 (1): 93-103. doi:10.1084/jem.20061598. PMID 17190838.
Roose JP, Mollenauer M, Ho M, et al. (2007). "Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.". Mol. Cell. Biol. 27 (7): 2732-45. doi:10.1128/MCB.01882-06. PMID 17283063.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Pasvolsky R, Feigelson SW, Kilic SS, et al. (2007). "A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.". J. Exp. Med. 204 (7): 1571-82. doi:10.1084/jem.20070058. PMID 17576779.
Kosco KA, Cerignoli F, Williams S, et al. (2007). "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.". Mol. Immunol. 45 (2): 510-22. doi:10.1016/j.molimm.2007.05.024. PMID 17658605.
Yasuda S, Stevens RL, Terada T, et al. (2007). "Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus.". J. Immunol. 179 (7): 4890-900. PMID 17878389.