RASGRF2

From Wikipedia, the free encyclopedia

Ras protein-specific guanine nucleotide-releasing factor 2

Identifiers

RASGRF2; GRF2; DKFZp781H1715; RAS-GRF2

External IDs

OMIM: 606614 MGI: 109137 HomoloGene: 2169

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

n/a

Refseq

NM_006909 (mRNA)
NP_008840 (protein)

NM_009027 (mRNA)
NP_033053 (protein)

Location

Chr 5: 80.29 - 80.56 Mb

n/a

Pubmed search

[1]

[2]

Ras protein-specific guanine nucleotide-releasing factor 2, also known as RASGRF2, is a human gene.^[1]

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2.

[edit] Further reading

Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene.". Genomics 39 (1): 118–20. doi:10.1006/geno.1996.4484. PMID 9027497.
Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.". Mol. Cell. Biol. 17 (3): 1396–406. PMID 9032266.
Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.". Curr. Biol. 8 (16): 935–8. PMID 9707409.
Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.". Mol. Cell. Biol. 19 (7): 4611–22. PMID 10373510.
Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.". Eur. J. Biochem. 269 (2): 638–49. PMID 11856323.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.". Mol. Cell. Biol. 24 (4): 1516–30. PMID 14749369.
Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer.". Oncol. Rep. 15 (5): 1281–5. PMID 16596198.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.". Mol. Cell. Biol. 27 (23): 8127–42. doi:10.1128/MCB.00912-07. PMID 17923690.