RASD1

From Wikipedia, the free encyclopedia

RAS, dexamethasone-induced 1

Identifiers

RASD1; AGS1; DEXRAS1; MGC:26290

External IDs

OMIM: 605550 MGI: 1270848 HomoloGene: 7509

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • guanyl-nucleotide exchange factor activity • GTP binding
Cellular Component:	• intracellular • membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016084 (mRNA)
NP_057168 (protein)

NM_009026 (mRNA)
NP_033052 (protein)

Location

Chr 17: 17.34 - 17.34 Mb

Chr 11: 59.78 - 59.78 Mb

Pubmed search

[1]

[2]

RAS, dexamethasone-induced 1, also known as RASD1, is a human gene.^[1]

This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASD1 RAS, dexamethasone-induced 1.

[edit] Further reading

Kemppainen RJ, Behrend EN (1998). "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells.". J. Biol. Chem. 273 (6): 3129-31. PMID 9452419.
Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.". Nat. Biotechnol. 17 (9): 878-83. doi:10.1038/12867. PMID 10471929.
Tu Y, Wu C (2000). "Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone.". Biochim. Biophys. Acta 1489 (2-3): 452-6. PMID 10673050.
Cismowski MJ, Ma C, Ribas C, et al. (2000). "Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration.". J. Biol. Chem. 275 (31): 23421-4. doi:10.1074/jbc.C000322200. PMID 10840027.
St Croix B, Rago C, Velculescu V, et al. (2000). "Genes expressed in human tumor endothelium.". Science 289 (5482): 1197-202. PMID 10947988.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Fang M, Jaffrey SR, Sawa A, et al. (2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.". Neuron 28 (1): 183-93. PMID 11086993.
Ognjanovic S, Bao S, Yamamoto SY, et al. (2001). "Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes.". J. Mol. Endocrinol. 26 (2): 107-17. PMID 11241162.
Takesono A, Nowak MW, Cismowski M, et al. (2002). "Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes.". J. Biol. Chem. 277 (16): 13827-30. doi:10.1074/jbc.M201064200. PMID 11842095.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.". Genome Res. 12 (5): 713-28. doi:10.1101/gr.73702. PMID 11997338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jaffrey SR, Fang M, Snyder SH (2003). "Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue.". Chem. Biol. 9 (12): 1329-35. PMID 12498886.
Kemppainen RJ, Cox E, Behrend EN, et al. (2003). "Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene.". Biochim. Biophys. Acta 1627 (2-3): 85-9. PMID 12818426.
Vaidyanathan G, Cismowski MJ, Wang G, et al. (2004). "The Ras-related protein AGS1/RASD1 suppresses cell growth.". Oncogene 23 (34): 5858-63. doi:10.1038/sj.onc.1207774. PMID 15184869.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Hiskens R, Vatish M, Hill C, et al. (2005). "Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.". Biochem. Biophys. Res. Commun. 337 (4): 1038-46. doi:10.1016/j.bbrc.2005.09.149. PMID 16225846.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Nguyen CH, Watts VJ (2006). "Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling.". Mol. Pharmacol. 69 (5): 1763-71. doi:10.1124/mol.105.019133. PMID 16489124.