RASA4

From Wikipedia, the free encyclopedia

RAS p21 protein activator 4

Identifiers

RASA4; CAPRI; GAPL; KIAA0538; MGC131890

External IDs

OMIM: 607943 MGI: 1858600 HomoloGene: 5080

Gene ontology
Molecular Function:	• GTPase activator activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular
Biological Process:	• intracellular signaling cascade • regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

n/a

Refseq

XM_001125752 (mRNA)
XP_001125752 (protein)

XM_977391 (mRNA)
XP_982485 (protein)

Location

n/a

Chr 5: 136.37 - 136.4 Mb

Pubmed search

[1]

[2]

RAS p21 protein activator 4, also known as RASA4, is a human gene.^[1]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASA4 RAS p21 protein activator 4.

[edit] Further reading

Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Lockyer PJ, Kupzig S, Cullen PJ (2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.". Curr. Biol. 11 (12): 981–6. PMID 11448776.
Minagawa T, Fukuda M, Mikoshiba K (2001). "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538.". Biochem. Biophys. Res. Commun. 288 (1): 87–90. doi:10.1006/bbrc.2001.5740. PMID 11594756.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Liu Q, Walker SA, Gao D, et al. (2005). "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.". J. Cell Biol. 170 (2): 183–90. doi:10.1083/jcb.200504167. PMID 16009725.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.