RASA3

From Wikipedia, the free encyclopedia

RAS p21 protein activator 3

Identifiers

RASA3; GAP1IP4BP; GAPIII; MGC46517; MGC47588

External IDs

OMIM: 605182 MGI: 1197013 HomoloGene: 7217

Gene ontology
Molecular Function:	• GTPase activator activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • plasma membrane
Biological Process:	• intracellular signaling cascade • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007368 (mRNA)
NP_031394 (protein)

NM_009025 (mRNA)
NP_033051 (protein)

Location

Chr 13: 113.77 - 113.92 Mb

Chr 8: 13.57 - 13.68 Mb

Pubmed search

[1]

[2]

RAS p21 protein activator 3, also known as RASA3, is a human gene.^[1]

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.^[1]

[edit] References

^ ^a ^b Entrez Gene: RASA3 RAS p21 protein activator 3.

[edit] Further reading

Hata Y, Kikuchi A, Sasaki T, et al. (1990). "Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.". J. Biol. Chem. 265 (13): 7104-7. PMID 2158984.
Cullen PJ, Hsuan JJ, Truong O, et al. (1995). "Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family.". Nature 376 (6540): 527-30. doi:10.1038/376527a0. PMID 7637787.
Hjermstad SJ, Briggs SD, Smithgall TE (1993). "Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism.". Biochemistry 32 (39): 10519-25. PMID 7691175.
Briggs SD, Bryant SS, Jove R, et al. (1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck.". J. Biol. Chem. 270 (24): 14718-24. PMID 7782336.
Lockyer PJ, Bottomley JR, Reynolds JS, et al. (1998). "Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.". Curr. Biol. 7 (12): 1007-10. PMID 9382842.
Lockyer PJ, Vanlingen S, Reynolds JS, et al. (1999). "Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m).". Biochem. Biophys. Res. Commun. 255 (2): 421-6. doi:10.1006/bbrc.1999.0217. PMID 10049724.
El-Daher SS, Patel Y, Siddiqua A, et al. (2000). "Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.". Blood 95 (11): 3412-22. PMID 10828023.
Cozier GE, Lockyer PJ, Reynolds JS, et al. (2000). "GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.". J. Biol. Chem. 275 (36): 28261-8. doi:10.1074/jbc.M000469200. PMID 10869341.
Koehler JA, Moran MF (2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP.". Biochem. Biophys. Res. Commun. 283 (4): 888-95. doi:10.1006/bbrc.2001.4889. PMID 11350068.
Walker SA, Kupzig S, Lockyer PJ, et al. (2003). "Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis.". J. Biol. Chem. 277 (50): 48779-85. doi:10.1074/jbc.M204839200. PMID 12356770.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.