RAPGEF5

From Wikipedia, the free encyclopedia

Rap guanine nucleotide exchange factor (GEF) 5

PDB rendering based on 1wgy.

Available structures: 1wgy

Identifiers

Symbol(s)

RAPGEF5; GFR; KIAA0277; MR-GEF; REPAC

External IDs

OMIM: 609527 MGI: 2444365 HomoloGene: 56563

Gene ontology
Molecular Function:	• DNA binding • guanyl-nucleotide exchange factor activity • oxidoreductase activity • Rap guanyl-nucleotide exchange factor activity • GTP-dependent protein binding
Cellular Component:	• intracellular • nucleus • phycobilisome
Biological Process:	• electron transport • transcription • regulation of transcription, DNA-dependent • small GTPase mediated signal transduction • nervous system development • photosynthesis • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_928602 (mRNA)
XP_933695 (protein)

NM_175930 (mRNA)
NP_787126 (protein)

Location

Chr 7: 22.13 - 22.36 Mb

Chr 12: 118.02 - 118.2 Mb

Pubmed search

[1]

[2]

Rap guanine nucleotide exchange factor (GEF) 5, also known as RAPGEF5, is a human gene.^[1]

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Ichiba T, Hoshi Y, Eto Y, et al. (1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1.". FEBS Lett. 457 (1): 85–9. PMID 10486569.
de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dupuy AG, L'Hoste S, Cherfils J, et al. (2005). "Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.". Oncogene 24 (28): 4509–20. doi:10.1038/sj.onc.1208647. PMID 15856025.