RAPGEF4

From Wikipedia, the free encyclopedia

Rap guanine nucleotide exchange factor (GEF) 4

PDB rendering based on 1o7f.

Available structures: 1o7f, 2byv

Identifiers

Symbol(s)

RAPGEF4; CAMP-GEFII; CGEF2; EPAC2; Nbla00496

External IDs

OMIM: 606058 MGI: 1917723 HomoloGene: 4451

Gene ontology
Molecular Function:	• nucleotide binding • guanyl-nucleotide exchange factor activity • protein binding • cAMP-dependent protein kinase regulator activity • cAMP binding
Cellular Component:	• intracellular • membrane fraction • cytosol • cAMP-dependent protein kinase complex
Biological Process:	• protein amino acid phosphorylation • G-protein coupled receptor protein signaling pathway • calcium ion-dependent exocytosis • regulation of exocytosis • cAMP-mediated signaling • insulin secretion • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007023 (mRNA)
NP_008954 (protein)

NM_019688 (mRNA)
NP_062662 (protein)

Location

Chr 2: 173.31 - 173.63 Mb

Chr 2: 71.78 - 72.06 Mb

Pubmed search

[1]

[2]

Rap guanine nucleotide exchange factor (GEF) 4, also known as RAPGEF4, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4.

[edit] Further reading

Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together.". Exp. Hematol. 30 (10): 1089-106. PMID 12384139.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Kawasaki H, Springett GM, Mochizuki N, et al. (1999). "A family of cAMP-binding proteins that directly activate Rap1.". Science 282 (5397): 2275-9. PMID 9856955.
de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.". J. Biol. Chem. 275 (27): 20829-36. doi:10.1074/jbc.M001113200. PMID 10777494.
Ozaki N, Shibasaki T, Kashima Y, et al. (2001). "cAMP-GEFII is a direct target of cAMP in regulated exocytosis.". Nat. Cell Biol. 2 (11): 805-11. doi:10.1038/35041046. PMID 11056535.
Coppola T, Magnin-Luthi S, Perret-Menoud V, et al. (2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.". J. Biol. Chem. 276 (35): 32756-62. doi:10.1074/jbc.M100929200. PMID 11438518.
Kashima Y, Miki T, Shibasaki T, et al. (2002). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion.". J. Biol. Chem. 276 (49): 46046-53. doi:10.1074/jbc.M108378200. PMID 11598134.
Ueno H, Shibasaki T, Iwanaga T, et al. (2002). "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform.". Genomics 78 (1-2): 91-8. doi:10.1006/geno.2001.6641. PMID 11707077.
Rehmann H, Prakash B, Wolf E, et al. (2007). "Structure and regulation of the cAMP-binding domains of Epac2.". Nat. Struct. Biol. 10 (1): 26-32. doi:10.1038/nsb878. PMID 12469113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bacchelli E, Blasi F, Biondolillo M, et al. (2004). "Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene.". Mol. Psychiatry 8 (11): 916-24. doi:10.1038/sj.mp.4001340. PMID 14593429.
Shibasaki T, Sunaga Y, Fujimoto K, et al. (2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.". J. Biol. Chem. 279 (9): 7956-61. doi:10.1074/jbc.M309068200. PMID 14660679.
Magiera MM, Gupta M, Rundell CJ, et al. (2005). "Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A.". Biochem. J. 382 (Pt 3): 803-10. doi:10.1042/BJ20040122. PMID 15202935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Dupuy AG, L'Hoste S, Cherfils J, et al. (2005). "Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.". Oncogene 24 (28): 4509-20. doi:10.1038/sj.onc.1208647. PMID 15856025.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Ster J, De Bock F, Guérineau NC, et al. (2007). "Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons.". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2519-24. doi:10.1073/pnas.0611031104. PMID 17284589.