RAPGEF3

From Wikipedia, the free encyclopedia

Rap guanine nucleotide exchange factor (GEF) 3

Identifiers

RAPGEF3; CAMP-GEFI; EPAC; EPAC1; MGC21410; bcm910

External IDs

OMIM: 606057 MGI: 2441741 HomoloGene: 21231

Gene ontology
Molecular Function:	• nucleotide binding • guanyl-nucleotide exchange factor activity • cAMP-dependent protein kinase regulator activity • cAMP binding
Cellular Component:	• intracellular • membrane fraction • cAMP-dependent protein kinase complex
Biological Process:	• protein amino acid phosphorylation • small GTPase mediated signal transduction • cell proliferation • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006105 (mRNA)
NP_006096 (protein)

NM_144850 (mRNA)
NP_659099 (protein)

Location

Chr 12: 46.42 - 46.44 Mb

Chr 15: 97.57 - 97.6 Mb

Pubmed search

[1]

[2]

Rap guanine nucleotide exchange factor (GEF) 3, also known as RAPGEF3, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3.

[edit] Further reading

Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together.". Exp. Hematol. 30 (10): 1089–106. PMID 12384139.
de Rooij J, Zwartkruis FJ, Verheijen MH, et al. (1998). "Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.". Nature 396 (6710): 474–7. doi:10.1038/24884. PMID 9853756.
Kawasaki H, Springett GM, Mochizuki N, et al. (1999). "A family of cAMP-binding proteins that directly activate Rap1.". Science 282 (5397): 2275–9. PMID 9856955.
de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Mei FC, Qiao J, Tsygankova OM, et al. (2002). "Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.". J. Biol. Chem. 277 (13): 11497–504. doi:10.1074/jbc.M110856200. PMID 11801596.
Qiao J, Mei FC, Popov VL, et al. (2002). "Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.". J. Biol. Chem. 277 (29): 26581–6. doi:10.1074/jbc.M203571200. PMID 12000763.
Rehmann H, Prakash B, Wolf E, et al. (2007). "Structure and regulation of the cAMP-binding domains of Epac2.". Nat. Struct. Biol. 10 (1): 26–32. doi:10.1038/nsb878. PMID 12469113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ohba Y, Kurokawa K, Matsuda M (2003). "Mechanism of the spatio-temporal regulation of Ras and Rap1.". EMBO J. 22 (4): 859–69. doi:10.1093/emboj/cdg087. PMID 12574122.
Rehmann H, Rueppel A, Bos JL, Wittinghofer A (2003). "Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.". J. Biol. Chem. 278 (26): 23508–14. doi:10.1074/jbc.M301680200. PMID 12707263.
Hochbaum D, Tanos T, Ribeiro-Neto F, et al. (2003). "Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger.". J. Biol. Chem. 278 (36): 33738–46. doi:10.1074/jbc.M305208200. PMID 12783872.
Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.". Blood 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Magiera MM, Gupta M, Rundell CJ, et al. (2005). "Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A.". Biochem. J. 382 (Pt 3): 803–10. doi:10.1042/BJ20040122. PMID 15202935.
Enserink JM, Price LS, Methi T, et al. (2004). "The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.". J. Biol. Chem. 279 (43): 44889–96. doi:10.1074/jbc.M404599200. PMID 15302884.
Keiper M, Stope MB, Szatkowski D, et al. (2004). "Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.". J. Biol. Chem. 279 (45): 46497–508. doi:10.1074/jbc.M403604200. PMID 15319437.
Cullere X, Shaw SK, Andersson L, et al. (2005). "Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.". Blood 105 (5): 1950–5. doi:10.1182/blood-2004-05-1987. PMID 15374886.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.