RAP2A

From Wikipedia, the free encyclopedia

RAP2A, member of RAS oncogene family

PDB rendering based on 1kao.

Available structures: 1kao, 2rap, 3rap

Identifiers

Symbol(s)

RAP2A; K-REV; KREV; RAP2; RbBP-30

External IDs

OMIM: 179540 MGI: 97855 HomoloGene: 10875

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• intracellular • membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021033 (mRNA)
NP_066361 (protein)

NM_029519 (mRNA)
NP_083795 (protein)

Location

Chr 13: 96.88 - 96.92 Mb

Chr 14: 119.61 - 119.64 Mb

Pubmed search

[1]

[2]

RAP2A, member of RAS oncogene family, also known as RAP2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAP2A RAP2A, member of RAS oncogene family.

[edit] Further reading

Lerosey I, Chardin P, de Gunzburg J, Tavitian A (1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.". J. Biol. Chem. 266 (7): 4315–21. PMID 1900290.
Pizon V, Chardin P, Lerosey I, et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.". Oncogene 3 (2): 201–4. PMID 3045729.
Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.". Biochem. J. 289 ( Pt 2): 349–55. PMID 8424780.
Cherfils J, Ménétrey J, Le Bras G, et al. (1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.". EMBO J. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMID 9312017.
Janoueix-Lerosey I, Pasheva E, de Tand MF, et al. (1998). "Identification of a specific effector of the small GTP-binding protein Rap2.". Eur. J. Biochem. 252 (2): 290–8. PMID 9523700.
Nancy V, Wolthuis RM, de Tand MF, et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.". J. Biol. Chem. 274 (13): 8737–45. PMID 10085114.
Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.". J. Biol. Chem. 274 (19): 13556–62. PMID 10224125.
Ménétrey J, Cherfils J (2000). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP.". Proteins 37 (3): 465–73. PMID 10591105.
de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Traver S, Bidot C, Spassky N, et al. (2001). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.". Biochem. J. 350 Pt 1: 19–29. PMID 10926822.
Gao X, Satoh T, Liao Y, et al. (2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras.". J. Biol. Chem. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Song C, Satoh T, Edamatsu H, et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon.". Oncogene 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kuiperij HB, de Rooij J, Rehmann H, et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.". Biochim. Biophys. Acta 1593 (2-3): 141–9. PMID 12581858.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Machida N, Umikawa M, Takei K, et al. (2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.". J. Biol. Chem. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.