RAP1A

From Wikipedia, the free encyclopedia

RAP1A, member of RAS oncogene family

PDB rendering based on 1c1y.

Available structures: 1c1y, 1gua

Identifiers

Symbol(s)

RAP1A; KREV-1; KREV1; RAP1; SMGP21

External IDs

OMIM: 179520 MGI: 97852 HomoloGene: 2162

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• intracellular • membrane
Biological Process:	• cell cycle • signal transduction • small GTPase mediated signal transduction • negative regulation of progression through cell cycle

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001010935 (mRNA)
NP_001010935 (protein)

NM_145541 (mRNA)
NP_663516 (protein)

Location

Chr 1: 111.89 - 112.06 Mb

n/a

Pubmed search

[1]

[2]

RAP1A, member of RAS oncogene family, also known as RAP1A, is a human gene.

The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.^[1]