RANBP9

From Wikipedia, the free encyclopedia

RAN binding protein 9

Identifiers

External IDs

OMIM: 603854 MGI: 1928741 HomoloGene: 38057

Gene ontology
Molecular Function:	• protein binding • Ran GTPase binding
Cellular Component:	• nucleus • cytoplasm • microtubule associated complex
Biological Process:	• protein complex assembly • microtubule nucleation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005493 (mRNA)
NP_005484 (protein)

XM_977383 (mRNA)
XP_982477 (protein)

Location

Chr 6: 13.73 - 13.82 Mb

Chr 13: 43.41 - 43.49 Mb

Pubmed search

[1]

[2]

RAN binding protein 9, also known as RANBP9, is a human gene.^[1]

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.^[1]

[edit] References

^ ^a ^b Entrez Gene: RANBP9 RAN binding protein 9.

[edit] Further reading

Nishimoto T (1999). "A new role of ran GTPase.". Biochem. Biophys. Res. Commun. 262 (3): 571–4. doi:10.1006/bbrc.1999.1252. PMID 10471364.
Kozak M (2003). "Emerging links between initiation of translation and human diseases.". Mamm. Genome 13 (8): 401–10. doi:10.1007/s00335-002-4002-5. PMID 12226704.
Nakamura M, Masuda H, Horii J, et al. (1998). "When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin.". J. Cell Biol. 143 (4): 1041–52. PMID 9817760.
Nishitani H, Hirose E, Uchimura Y, et al. (2001). "Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex.". Gene 272 (1-2): 25–33. PMID 11470507.
Caballero OL, Resto V, Patturajan M, et al. (2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).". Oncogene 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530.
Ideguchi H, Ueda A, Tanaka M, et al. (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMID 12084015.
Wang D, Li Z, Messing EM, Wu G (2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM.". J. Biol. Chem. 277 (39): 36216–22. doi:10.1074/jbc.M205111200. PMID 12147692.
Wang Y, Marion Schneider E, Li X, et al. (2002). "HIPK2 associates with RanBPM.". Biochem. Biophys. Res. Commun. 297 (1): 148–53. PMID 12220523.
Rao MA, Cheng H, Quayle AN, et al. (2003). "RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor.". J. Biol. Chem. 277 (50): 48020–7. doi:10.1074/jbc.M209741200. PMID 12361945.
Emberley ED, Gietz RD, Campbell JD, et al. (2003). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer.". BMC Cancer 2: 28. PMID 12421467.
Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.". Biochem. Biophys. Res. Commun. 299 (5): 793–800. PMID 12470648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.". Gene 303: 47–54. PMID 12559565.
Lutz W, Frank EM, Craig TA, et al. (2003). "Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy.". Biochem. Biophys. Res. Commun. 303 (4): 1186–92. PMID 12684061.
Yao X, Wang HL, Shi ZX, et al. (2003). "Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast.". World J. Gastroenterol. 9 (6): 1347–51. PMID 12800254.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.". Hum. Mol. Genet. 12 (13): 1591–608. PMID 12812986.
Zou Y, Lim S, Lee K, et al. (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
Mikolajczyk M, Shi J, Vaillancourt RR, et al. (2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.". Biochem. Biophys. Res. Commun. 310 (1): 14–8. PMID 14511641.