RANBP5

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RAN binding protein 5

Identifiers

Symbol(s)

RANBP5; DKFZp686O1576; FLJ43041; IMB3; IPO5; KPNB3; MGC2068

External IDs

OMIM: 602008 MGI: 1917822 HomoloGene: 1710

Gene ontology
Molecular Function:	• GTPase inhibitor activity • binding • protein binding • nuclear localization sequence binding • Ran GTPase binding • protein transporter activity
Cellular Component:	• nucleus • nuclear pore • cytoplasm
Biological Process:	• protein import into nucleus, docking • NLS-bearing substrate import into nucleus • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002271 (mRNA)
NP_002262 (protein)

NM_023579 (mRNA)
NP_076068 (protein)

Location

Chr 13: 97.4 - 97.47 Mb

n/a

Pubmed search

[1]

[2]

RAN binding protein 5, also known as RANBP5, is a human gene.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.^[1]

[edit] References

^ Entrez Gene: RANBP5 RAN binding protein 5.

[edit] Further reading

Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader.". Front. Biosci. 2: d578–87. PMID 9366553.
Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.". Mol. Med. 4 (3): 138–43. PMID 9562972.
Christophe D, Christophe-Hobertus C, Pichon B (2000). "Nuclear targeting of proteins: how many different signals?". Cell. Signal. 12 (5): 337–41. PMID 10822175.
Chook YM, Blobel G (2002). "Karyopherins and nuclear import.". Curr. Opin. Struct. Biol. 11 (6): 703–15. PMID 11751052.
Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. PMID 1631159.
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.". Nature 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. PMID 9114010.
Deane R, Schäfer W, Zimmermann HP, et al. (1997). "Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1.". Mol. Cell. Biol. 17 (9): 5087–96. PMID 9271386.
Gallay P, Hope T, Chin D, Trono D (1997). "HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. PMID 9275210.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Henderson BR, Percipalle P (1998). "Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.". J. Mol. Biol. 274 (5): 693–707. doi:10.1006/jmbi.1997.1420. PMID 9405152.
Efthymiadis A, Briggs LJ, Jans DA (1998). "The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties.". J. Biol. Chem. 273 (3): 1623–8. PMID 9430704.
Vodicka MA, Koepp DM, Silver PA, Emerman M (1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection.". Genes Dev. 12 (2): 175–85. PMID 9436978.
Popov S, Rexach M, Zybarth G, et al. (1998). "Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.". EMBO J. 17 (4): 909–17. doi:10.1093/emboj/17.4.909. PMID 9463369.
Popov S, Rexach M, Ratner L, et al. (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex.". J. Biol. Chem. 273 (21): 13347–52. PMID 9582382.
Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.". J. Virol. 72 (7): 6004–13. PMID 9621063.