RANBP3

From Wikipedia, the free encyclopedia

RAN binding protein 3

PDB rendering based on 2crf.

Available structures: 2crf

Identifiers

Symbol(s)

RANBP3; DKFZp586I1520

External IDs

OMIM: 603327 MGI: 1919060 HomoloGene: 37828

Gene ontology
Molecular Function:	• protein binding • Ran GTPase binding
Cellular Component:	• nucleus • nuclear pore
Biological Process:	• small GTPase mediated signal transduction • protein transport • intracellular transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003624 (mRNA)
NP_003615 (protein)

NM_027933 (mRNA)
NP_082209 (protein)

Location

Chr 19: 5.87 - 5.93 Mb

Chr 17: 56.36 - 56.4 Mb

Pubmed search

[1]

[2]

RAN binding protein 3, also known as RANBP3, is a human gene.^[1]

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: RANBP3 RAN binding protein 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Mueller L, Cordes VC, Bischoff FR, Ponstingl H (1998). "Human RanBP3, a group of nuclear RanGTP binding proteins.". FEBS Lett. 427 (3): 330-6. PMID 9637251.
Lindsay ME, Holaska JM, Welch K, et al. (2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.". J. Cell Biol. 153 (7): 1391-402. PMID 11425870.
Englmeier L, Fornerod M, Bischoff FR, et al. (2002). "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.". EMBO Rep. 2 (10): 926-32. doi:10.1093/embo-reports/kve200. PMID 11571268.
Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.". J. Biol. Chem. 277 (20): 17385-8. doi:10.1074/jbc.C100620200. PMID 11932251.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hakata Y, Yamada M, Shida H (2003). "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.". Mol. Cell. Biol. 23 (23): 8751-61. PMID 14612415.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.