RANBP2

From Wikipedia, the free encyclopedia

RAN binding protein 2

PDB rendering based on 1rrp.

Available structures: 1rrp, 1xke, 1z5s

Identifiers

Symbol(s)

RANBP2; TRP1; NUP358; TRP2

External IDs

OMIM: 601181 MGI: 894323 HomoloGene: 68510

Gene ontology
Molecular Function:	• peptidyl-prolyl cis-trans isomerase activity • protein binding • zinc ion binding • Ran GTPase binding • isomerase activity • metal ion binding
Cellular Component:	• intracellular • nucleus • nuclear pore
Biological Process:	• protein folding • ubiquitin cycle • protein import into nucleus • intracellular transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006267 (mRNA)
NP_006258 (protein)

XM_972831 (mRNA)
XP_977925 (protein)

Location

Chr 2: 108.7 - 108.77 Mb

Chr 10: 57.84 - 57.89 Mb

Pubmed search

[1]

[2]

RAN binding protein 2, also known as RANBP2, is a human gene.

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.^[1]

[edit] References

^ Entrez Gene: RANBP2 RAN binding protein 2.

[edit] Further reading

Ferreira PA, Hom JT, Pak WL (1995). "Retina-specifically expressed novel subtypes of bovine cyclophilin.". J. Biol. Chem. 270 (39): 23179–88. PMID 7559465.
Yokoyama N, Hayashi N, Seki T, et al. (1995). "A giant nucleopore protein that binds Ran/TC4.". Nature 376 (6536): 184–8. doi:10.1038/376184a0. PMID 7603572.
Beddow AL, Richards SA, Orem NR, Macara IG (1995). "The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3328–32. PMID 7724562.
Wu J, Matunis MJ, Kraemer D, et al. (1995). "Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region.". J. Biol. Chem. 270 (23): 14209–13. PMID 7775481.
Bischoff FR, Krebber H, Smirnova E, et al. (1995). "Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.". EMBO J. 14 (4): 705–15. PMID 7882974.
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.". Nature 383 (6601): 637–40. doi:10.1038/383637a0. PMID 8857542.
Mahajan R, Delphin C, Guan T, et al. (1997). "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.". Cell 88 (1): 97–107. PMID 9019411.
Ferreira PA, Nakayama TA, Travis GH (1997). "Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1556–61. PMID 9037092.
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. PMID 9114010.
Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. PMID 9144189.
Krebber H, Bastians H, Hoheisel J, et al. (1997). "Localization of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-q13 by fluorescence in situ hybridization.". Genomics 43 (2): 247–8. doi:10.1006/geno.1997.4777. PMID 9244446.
Delphin C, Guan T, Melchior F, Gerace L (2000). "RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex.". Mol. Biol. Cell 8 (12): 2379–90. PMID 9398662.
Nothwang HG, Rensing C, Kübler M, et al. (1998). "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.". Genomics 47 (3): 383–92. doi:10.1006/geno.1997.5119. PMID 9480752.
Ferreira PA, Yunfei C, Schick D, Roepman R (1998). "The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.". J. Biol. Chem. 273 (38): 24676–82. PMID 9733766.
Vetter IR, Nowak C, Nishimoto T, et al. (1999). "Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.". Nature 398 (6722): 39–46. doi:10.1038/17969. PMID 10078529.
Yaseen NR, Blobel G (1999). "Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5516–21. PMID 10318915.
Yaseen NR, Blobel G (1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.". J. Biol. Chem. 274 (37): 26493–502. PMID 10473610.
Singh BB, Patel HH, Roepman R, et al. (2000). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.". J. Biol. Chem. 274 (52): 37370–8. PMID 10601307.
Ben-Efraim I, Gerace L (2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.". J. Cell Biol. 152 (2): 411–7. PMID 11266456.
Fauser S, Aslanukov A, Roepman R, Ferreira PA (2001). "Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene". Mamm. Genome 12 (6): 406–15. doi:10.1007/s003350010291. PMID 11353387.
Mavlyutov TA, Cai Y, Ferreira PA (2002). "Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization". Traffic. 3 (9): 630–40. doi:10.1034/j.1600-0854.2002.30905.x. PMID 12191015.
Aslanukov A, Bhowmick R, Guruju M, Oswald J, Raz D, Bush RA, Sieving PA, Lu X, Bock CB, Ferreira PA. (2006). "RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism". PLoS Genet. 2 (10): e177. doi:10.1371/journal.pgen.0020177. PMID 17069463.
Cho KI, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira PA (2007). "Association of the Kinesin-Binding Domain of RanBP2 to KIF5B and KIF5C Determines Mitochondria Localization and Function". Traffic 8 (12): 1722–1735. doi:10.1111/j.1600-0854.2007.00647.x. PMID 17887960.
Yi H, Friedman J, Ferreira PA. (2007). "The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis". J Biol Chem. 282 (48): 34770–8. doi:10.1074/jbc.M706903200. PMID 17911097.