RALGDS

From Wikipedia, the free encyclopedia

Ral guanine nucleotide dissociation stimulator

PDB rendering based on 1lfd.

Available structures: 1lfd, 1lxd, 1rax, 2b3a, 2rgf

Identifiers

Symbol(s)

RALGDS; FLJ20922; RGF; RalGEF

External IDs

OMIM: 601619 MGI: 107485 HomoloGene: 4562

Gene ontology
Molecular Function:	• small GTPase regulator activity • guanyl-nucleotide exchange factor activity • protein binding
Cellular Component:	• cellular_component • intracellular
Biological Process:	• signal transduction • small GTPase mediated signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042368 (mRNA)
NP_001035827 (protein)

NM_009058 (mRNA)
NP_033084 (protein)

Location

Chr 9: 134.96 - 135.01 Mb

Chr 2: 28.34 - 28.38 Mb

Pubmed search

[1]

[2]

Ral guanine nucleotide dissociation stimulator, also known as RALGDS, is a human gene.^[1]

[edit] References

^ Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator.

[edit] Further reading

Spaargaren M, Bischoff JR (1995). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMID 7809086.
Hofer F, Fields S, Schneider C, Martin GS (1994). "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11089-93. PMID 7972015.
Albright CF, Giddings BW, Liu J, et al. (1993). "Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.". EMBO J. 12 (1): 339-47. PMID 8094051.
Urano T, Emkey R, Feig LA (1996). "Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.". EMBO J. 15 (4): 810-6. PMID 8631302.
Miller MJ, Prigent S, Kupperman E, et al. (1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation.". J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.
Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.". EMBO J. 16 (8): 1921-33. doi:10.1093/emboj/16.8.1921. PMID 9155018.
Geyer M, Herrmann C, Wohlgemuth S, et al. (1997). "Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.". Nat. Struct. Biol. 4 (9): 694-9. PMID 9302994.
Humphrey D, Kwiatkowska J, Henske EP, et al. (1997). "Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1.". Ann. Hum. Genet. 61 (Pt 4): 299-305. doi:10.1046/j.1469-1809.1997.6140299.x. PMID 9365783.
Kimmelman A, Tolkacheva T, Lorenzi MV, et al. (1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution.". Oncogene 15 (22): 2675-85. doi:10.1038/sj.onc.1201674. PMID 9400994.
Shirouzu M, Morinaka K, Koyama S, et al. (1998). "Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS.". J. Biol. Chem. 273 (13): 7737-42. PMID 9516482.
Okada S, Matsuda M, Anafi M, et al. (1998). "Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.". EMBO J. 17 (9): 2554-65. doi:10.1093/emboj/17.9.2554. PMID 9564038.
Nancy V, Wolthuis RM, de Tand MF, et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.". J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.
Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line.". Blood 94 (7): 2433-44. PMID 10498616.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin.". Arch. Biochem. Biophys. 371 (2): 207-19. doi:10.1006/abbi.1999.1448. PMID 10545207.
Zheng Q, Yu L, Zhao Y, et al. (2000). "[Refined chromosome assignment of human novel H-RalGDS gene on chromosome 9q34.1 by using radiation hybrid genebridge 4 panel]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 17 (1): 1-5. PMID 10653898.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Zheng Q, Yu L, Zhao Y, et al. (2001). "Structure characterization of human RalGDS gene, and the identification of its novel variant.". Mol. Biol. Rep. 27 (4): 209-16. PMID 11455956.
Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.". J. Biol. Chem. 277 (12): 9966-75. doi:10.1074/jbc.M109059200. PMID 11788587.
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K.". Oncogene 21 (6): 937-46. doi:10.1038/sj.onc.1205144. PMID 11840339.
Tian X, Rusanescu G, Hou W, et al. (2002). "PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.". EMBO J. 21 (6): 1327-38. doi:10.1093/emboj/21.6.1327. PMID 11889038.