RAET1E

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Retinoic acid early transcript 1E
Identifiers
Symbol(s) RAET1E; LETAL; MGC125308; MGC125309; ULBP4; bA350J20.7
External IDs OMIM: 609243 HomoloGene: 51400
Orthologs
Human Mouse
Entrez 135250 n/a
Ensembl ENSG00000164520 n/a
Uniprot Q8TD07 n/a
Refseq NM_139165 (mRNA)
NP_631904 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 6: 150.25 - 150.25 Mb n/a
Pubmed search [1] n/a

Retinoic acid early transcript 1E, also known as RAET1E, is a human gene.[1]

Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. (Radosavljevic et al., 2002).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: RAET1E retinoic acid early transcript 1E.

[edit] Further reading

  • Radosavljevic M, Cuillerier B, Wilson MJ, et al. (2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.". Genomics 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chalupny NJ, Sutherland CL, Lawrence WA, et al. (2003). "ULBP4 is a novel ligand for human NKG2D.". Biochem. Biophys. Res. Commun. 305 (1): 129–35. PMID 12732206. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Conejo-Garcia JR, Benencia F, Courreges MC, et al. (2004). "Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.". Cancer Biol. Ther. 2 (4): 446–51. PMID 14508119. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Conejo-Garcia JR, Benencia F, Courreges MC, et al. (2004). "Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells.". Cancer Res. 64 (6): 2175–82. PMID 15026360. 
  • Bacon L, Eagle RA, Meyer M, et al. (2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.". J. Immunol. 173 (2): 1078–84. PMID 15240696. 
  • Cao W, Xi X, Hao Z, et al. (2007). "RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.". J. Biol. Chem. 282 (26): 18922–8. doi:10.1074/jbc.M702504200. PMID 17470428. 
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