RAD54B

From Wikipedia, the free encyclopedia

RAD54 homolog B (S. cerevisiae)

Identifiers

External IDs

OMIM: 604289 MGI: 2444973 HomoloGene: 8240

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • DNA helicase activity • RNA helicase activity • ATP binding • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• DNA repair • mitotic recombination • transcription • regulation of transcription, DNA-dependent • meiotic recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001126364 (mRNA)
XP_001126364 (protein)

NM_001039556 (mRNA)
NP_001034645 (protein)

Location

Chr 8: 95.45 - 95.56 Mb

Chr 4: 11.49 - 11.54 Mb

Pubmed search

[1]

[2]

RAD54 homolog B (S. cerevisiae), also known as RAD54B, is a human gene.^[1]

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: RAD54B RAD54 homolog B (S. cerevisiae).

[edit] Further reading

Hiramoto T, Nakanishi T, Sumiyoshi T, et al. (1999). "Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.". Oncogene 18 (22): 3422–6. doi:10.1038/sj.onc.1202691. PMID 10362364.
Tanaka K, Hiramoto T, Fukuda T, Miyagawa K (2000). "A novel human rad54 homologue, Rad54B, associates with Rad51.". J. Biol. Chem. 275 (34): 26316–21. doi:10.1074/jbc.M910306199. PMID 10851248.
Miyagawa K, Tsuruga T, Kinomura A, et al. (2002). "A role for RAD54B in homologous recombination in human cells.". EMBO J. 21 (1-2): 175–80. doi:10.1093/emboj/21.1.175. PMID 11782437.
Tanaka K, Kagawa W, Kinebuchi T, et al. (2002). "Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54.". Nucleic Acids Res. 30 (6): 1346–53. PMID 11884632.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sehorn MG, Sigurdsson S, Bussen W, et al. (2004). "Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.". Nature 429 (6990): 433–7. doi:10.1038/nature02563. PMID 15164066.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Wesoly J, Agarwal S, Sigurdsson S, et al. (2006). "Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.". Mol. Cell. Biol. 26 (3): 976–89. doi:10.1128/MCB.26.3.976-989.2006. PMID 16428451.
Sarai N, Kagawa W, Kinebuchi T, et al. (2006). "Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein.". Nucleic Acids Res. 34 (16): 4429–37. doi:10.1093/nar/gkl562. PMID 16945962.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Bryś M, Nowacka-Zawisza M, Romanowicz-Makowska H, et al. (2007). "Loss of heterozygosity in the RAD54B region is not predictive for breast carcinomas.". Pol J Pathol 58 (1): 3–6. PMID 17585536.