RAD51L3

From Wikipedia, the free encyclopedia

RAD51-like 3 (S. cerevisiae)

Identifiers

RAD51L3; HsTRAD; R51H3; RAD51D; Trad

External IDs

OMIM: 602954 MGI: 1261809 HomoloGene: 2156

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • ATP binding • DNA-dependent ATPase activity • nucleoside-triphosphatase activity
Cellular Component:	• nucleus
Biological Process:	• DNA metabolic process • base-excision repair • meiotic recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002878 (mRNA)
NP_002869 (protein)

XM_489738 (mRNA)
XP_489738 (protein)

Location

Chr 17: 30.45 - 30.47 Mb

Chr 11: 82.69 - 82.71 Mb

Pubmed search

[1]

[2]

RAD51-like 3 (S. cerevisiae), also known as RAD51L3, is a human gene.^[1]

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae).

[edit] Further reading

Cartwright R, Dunn AM, Simpson PJ, et al. (1998). "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family.". Nucleic Acids Res. 26 (7): 1653–9. PMID 9512535.
Pittman DL, Weinberg LR, Schimenti JC (1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene.". Genomics 49 (1): 103–11. doi:10.1006/geno.1998.5226. PMID 9570954.
Kawabata M, Saeki K (1999). "Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the rec A/RAD51 gene family.". Biochem. Biophys. Res. Commun. 257 (1): 156–62. doi:10.1006/bbrc.1999.0413. PMID 10092526.
Schild D, Lio YC, Collins DW, et al. (2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs.". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
Braybrooke JP, Spink KG, Thacker J, Hickson ID (2000). "The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2.". J. Biol. Chem. 275 (37): 29100–6. doi:10.1074/jbc.M002075200. PMID 10871607.
Miller KA, Yoshikawa DM, McConnell IR, et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
Masson JY, Tarsounas MC, Stasiak AZ, et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs.". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMID 11751635.
Sigurdsson S, Van Komen S, Bussen W, et al. (2002). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMID 11751636.
Kurumizaka H, Ikawa S, Nakada M, et al. (2002). "Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.". J. Biol. Chem. 277 (16): 14315–20. doi:10.1074/jbc.M105719200. PMID 11834724.
Wiese C, Collins DW, Albala JS, et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.". Nucleic Acids Res. 30 (4): 1001–8. PMID 11842112.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.". Nucleic Acids Res. 30 (4): 1009–15. PMID 11842113.
Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.". Oncogene 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Braybrooke JP, Li JL, Wu L, et al. (2004). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Tarsounas M, Davies AA, West SC (2004). "RAD51 localization and activation following DNA damage.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 359 (1441): 87–93. doi:10.1098/rstb.2003.1368. PMID 15065660.
Tarsounas M, Muñoz P, Claas A, et al. (2004). "Telomere maintenance requires the RAD51D recombination/repair protein.". Cell 117 (3): 337–47. PMID 15109494.
Hussain S, Wilson JB, Medhurst AL, et al. (2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
Rodríguez-López R, Osorio A, Ribas G, et al. (2004). "The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations.". Int. J. Cancer 110 (6): 845–9. doi:10.1002/ijc.20169. PMID 15170666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.