From Wikipedia, the free encyclopedia
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Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
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| PDB rendering based on 1ds6. |
| Available structures: 1ds6, 1e96, 1foe, 1g4u, 1he1, 1hh4, 1i4d, 1i4l, 1i4t, 1mh1, 2fju, 2g0n, 2h7v, 2ic5, 2nz8, 2ov2, 2p2l |
| Identifiers |
| Symbol(s) |
RAC2; EN-7; Gx; HSPC022 |
| External IDs |
OMIM: 602049 MGI: 97846 HomoloGene: 55699 |
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| RNA expression pattern |
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More reference expression data
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| Orthologs |
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Human |
Mouse |
| Entrez |
5880 |
19354 |
| Ensembl |
ENSG00000128340 |
ENSMUSG00000033220 |
| Uniprot |
P15153 |
Q8CEV8 |
| Refseq |
NM_002872 (mRNA)
NP_002863 (protein) |
XM_001000836 (mRNA)
XP_001000836 (protein) |
| Location |
Chr 22: 35.95 - 35.97 Mb |
Chr 15: 78.39 - 78.4 Mb |
| Pubmed search |
[1] |
[2] |
Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RAC2.[2]
Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[2]
[edit] References
[edit] Further reading
- Mizuno T, Kaibuchi K, Ando S, et al. (1992). "Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.". J. Biol. Chem. 267 (15): 10215–8. PMID 1316893.
- Reibel L, Dorseuil O, Stancou R, et al. (1991). "A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation.". Biochem. Biophys. Res. Commun. 175 (2): 451–8. PMID 1902092.
- Kinsella BT, Erdman RA, Maltese WA (1991). "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA.". J. Biol. Chem. 266 (15): 9786–94. PMID 1903399.
- Didsbury J, Weber RF, Bokoch GM, et al. (1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates.". J. Biol. Chem. 264 (28): 16378–82. PMID 2674130.
- Kwong CH, Malech HL, Rotrosen D, Leto TL (1993). "Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.". Biochemistry 32 (21): 5711–7. PMID 8504089.
- Courjal F, Chuchana P, Theillet C, Fort P (1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes.". Genomics 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243.
- Gorvel JP, Chang TC, Boretto J, et al. (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.". FEBS Lett. 422 (2): 269–73. PMID 9490022.
- Dai Q, Choy E, Chiu V, et al. (1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.". J. Biol. Chem. 273 (24): 15030–4. PMID 9614111.
- Ahmed S, Prigmore E, Govind S, et al. (1998). "Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox).". J. Biol. Chem. 273 (25): 15693–701. PMID 9624165.
- Faris SL, Rinckel LA, Huang J, et al. (1998). "Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42.". Biochem. Biophys. Res. Commun. 247 (2): 271–6. doi:10.1006/bbrc.1998.8775. PMID 9642115.
- Zhang B, Zheng Y (1998). "Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.". J. Biol. Chem. 273 (40): 25728–33. PMID 9748241.
- Nishihara H, Kobayashi S, Hashimoto Y, et al. (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.". Biochim. Biophys. Acta 1452 (2): 179–87. PMID 10559471.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Scheffzek K, Stephan I, Jensen ON, et al. (2000). "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.". Nat. Struct. Biol. 7 (2): 122–6. doi:10.1038/72392. PMID 10655614.
- Ambruso DR, Knall C, Abell AN, et al. (2000). "Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4654–9. doi:10.1073/pnas.080074897. PMID 10758162.
- Williams DA, Tao W, Yang F, et al. (2000). "Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.". Blood 96 (5): 1646–54. PMID 10961859.
- Tamura M, Kai T, Tsunawaki S, et al. (2000). "Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase.". Biochem. Biophys. Res. Commun. 276 (3): 1186–90. doi:10.1006/bbrc.2000.3598. PMID 11027608.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
- Lapouge K, Smith SJ, Walker PA, et al. (2000). "Structure of the TPR domain of p67phox in complex with Rac.GTP.". Mol. Cell 6 (4): 899–907. PMID 11090627.
- Tarricone C, Xiao B, Justin N, et al. (2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.". Nature 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
