RAC1

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Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
PDB rendering based on 1ds6.
Available structures: 1ds6, 1e96, 1foe, 1g4u, 1he1, 1hh4, 1i4d, 1i4l, 1i4t, 1mh1, 1ryf, 1ryh, 2c2h, 2fju, 2g0n, 2h7v, 2ic5, 2nz8, 2ov2, 2p2l
Identifiers
Symbol(s) RAC1; MGC111543; MIG5; TC-25; p21-Rac1
External IDs OMIM: 602048 MGI: 97845 HomoloGene: 69035
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5879 19353
Ensembl ENSG00000136238 ENSMUSG00000001847
Uniprot P63000 Q8BPG5
Refseq NM_006908 (mRNA)
NP_008839 (protein)		 NM_009007 (mRNA)
NP_033033 (protein)
Location Chr 7: 6.38 - 6.41 Mb Chr 5: 143.76 - 143.78 Mb
Pubmed search [1] [2]

Rac1 (Ras-related C3 botulinum toxin substrate 1) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RAC1. It is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).

Contents

[edit] Gene

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

[edit] References

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. 
  2. ^ Entrez Gene: RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1).

[edit] Further reading

  • Benitah SA, Frye M, Glogauer M, Watt FM (2005). "Stem cell depletion through epidermal deletion of Rac1". Science 309 (5736): 933–5. doi:10.1126/science.1113579. PMID 16081735. 
  • Dorseuil O, Gacon G (1997). "[Signal transduction by Rac small G proteins in phagocytes]". C. R. Seances Soc. Biol. Fil. 191 (2): 237–46. PMID 9255350. 
  • Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition.". Trends Neurosci. 25 (4): 191–9. PMID 11998687. 

[edit] External links

v • d • e
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Elongation factor
3.6.5.5-6: Other
Dynamin (is a GTPase, is not a G protein) - Tubulin
v • d • e
Rho family of GTPases
Most studied
Cdc42 subclass
Rac subclass
RhoBTB subclass
RhoBTB1 - RhoBTB2
RhoH subclass
Rho subclass
Rnd subclass
RhoD subclass
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