RAB7A

From Wikipedia, the free encyclopedia

RAB7A, member RAS oncogene family

PDB rendering based on 1t91.

Available structures: 1t91, 1vg0, 1vg1, 1vg8, 1vg9, 1yhn

Identifiers

Symbol(s)

RAB7A; FLJ20819; PRO2706; RAB7

External IDs

OMIM: 602298 MGI: 105068 HomoloGene: 3408

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• lysosome • late endosome
Biological Process:	• endocytosis • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004637 (mRNA)
NP_004628 (protein)

NM_009005 (mRNA)
NP_033031 (protein)

Location

Chr 3: 129.93 - 130.02 Mb

n/a

Pubmed search

[1]

[2]

RAB7A, member RAS oncogene family, also known as RAB7A, is a human gene.

Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.[supplied by OMIM]^[1]