RAB5C

From Wikipedia, the free encyclopedia

RAB5C, member RAS oncogene family

PDB rendering based on 1huq.

Available structures: 1huq, 1n6h, 1n6i, 1n6k, 1n6l, 1n6n, 1n6o, 1n6p, 1n6r, 1r2q, 1tu3, 1tu4, 1z07, 1z0d

Identifiers

Symbol(s)

RAB5C; MGC117217; MGC138857; RAB5CL; RABL

External IDs

OMIM: 604037 MGI: 105306 HomoloGene: 55533

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• endocytic vesicle
Biological Process:	• endosome organization and biogenesis • small GTPase mediated signal transduction • protein transport • regulation of endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004583 (mRNA)
NP_004574 (protein)

NM_024456 (mRNA)
NP_077776 (protein)

Location

Chr 17: 37.53 - 37.56 Mb

Chr 11: 100.53 - 100.55 Mb

Pubmed search

[1]

[2]

RAB5C, member RAS oncogene family, also known as RAB5C, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB5C RAB5C, member RAS oncogene family.

[edit] Further reading

Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.". Nat. Genet. 7 (4): 472-9. doi:10.1038/ng0894-472. PMID 7951316.
Han HJ, Sudo K, Inazawa J, Nakamura Y (1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene.". Cytogenet. Cell Genet. 73 (1-2): 137-9. PMID 8646882.
Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells.". J. Biol. Chem. 273 (51): 33901-4. PMID 9852039.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657-62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.". Infect. Immun. 68 (5): 2671-84. PMID 10768959.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494-500. doi:10.1074/jbc.M211514200. PMID 12493736.
Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159-68. doi:10.1242/jcs.00718. PMID 12972505.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135-44. doi:10.1021/pr060363j. PMID 17081065.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.