RAB3GAP2

From Wikipedia, the free encyclopedia

RAB3 GTPase activating protein subunit 2 (non-catalytic)

Identifiers

RAB3GAP2; p150; DKFZP434D245; FLJ14579; KIAA0839; RAB3-GAP150; RAB3GAP150

External IDs

Gene ontology
Molecular Function:	• GTPase activator activity • protein heterodimerization activity
Cellular Component:	• soluble fraction
Biological Process:	• intracellular protein transport • regulation of GTPase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_012414 (mRNA)
NP_036546 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 218.39 - 218.51 Mb

n/a

Pubmed search

[1]

n/a

RAB3 GTPase activating protein subunit 2 (non-catalytic), also known as RAB3GAP2, is a human gene.^[1]

Members of the RAB3 protein family (see RAB3A; MIM 179490) are implicated in Ca(2+)-dependent exocytosis. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit (RAB3GAP1; MIM 602536) and a 150-kD noncatalytic subunit (RAB3GAP2) (Nagano et al., 1998).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic).

[edit] Further reading

Nagano F, Sasaki T, Fukui K, et al. (1998). "Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein.". J. Biol. Chem. 273 (38): 24781–5. PMID 9733780.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Aligianis IA, Johnson CA, Gissen P, et al. (2005). "Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome.". Nat. Genet. 37 (3): 221–3. doi:10.1038/ng1517. PMID 15696165.
Aligianis IA, Morgan NV, Mione M, et al. (2006). "Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic subunit in a kindred with Martsolf syndrome.". Am. J. Hum. Genet. 78 (4): 702–7. doi:10.1086/502681. PMID 16532399.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.