RAB2A

From Wikipedia, the free encyclopedia

RAB2A, member RAS oncogene family

PDB rendering based on 1z0a.

Available structures: 1z0a, 2a5j

Identifiers

Symbol(s)

RAB2A; RAB2

External IDs

OMIM: 179509 MGI: 1928750 HomoloGene: 20628

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• endoplasmic reticulum • Golgi apparatus
Biological Process:	• ER to Golgi vesicle-mediated transport • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002865 (mRNA)
NP_002856 (protein)

NM_021518 (mRNA)
NP_067493 (protein)

Location

Chr 8: 61.59 - 61.7 Mb

Chr 4: 8.46 - 8.53 Mb

Pubmed search

[1]

[2]

RAB2A, member RAS oncogene family, also known as RAB2A, is a human gene.^[1]

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RAB2A RAB2A, member RAS oncogene family.

[edit] Further reading

Khosravi-Far R, Lutz RJ, Cox AD, et al. (1991). "Isoprenoid modification of rab proteins terminating in CC or CXC motifs.". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6264–8. PMID 1648736.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394–401. PMID 2501306.
Tachibana K, Umezawa A, Kato S, Takano T (1989). "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily.". Nucleic Acids Res. 16 (21): 10368. PMID 3057444.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Tisdale EJ, Balch WE (1997). "Rab2 is essential for the maturation of pre-Golgi intermediates.". J. Biol. Chem. 271 (46): 29372–9. PMID 8910601.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
de Leeuw HP, Koster PM, Calafat J, et al. (1998). "Small GTP-binding proteins in human endothelial cells.". Br. J. Haematol. 103 (1): 15–9. PMID 9792283.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.". Biochemistry 38 (36): 11711–21. PMID 10512627.
Caillol N, Pasqualini E, Lloubes R, Lombardo D (2000). "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells.". J. Cell. Biochem. 79 (4): 628–47. PMID 10996854.
Short B, Preisinger C, Körner R, et al. (2002). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMID 11739401.
Ni X, Ma Y, Cheng H, et al. (2002). "Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.". J. Hum. Genet. 47 (10): 548–51. doi:10.1007/s100380200083. PMID 12376746.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tisdale EJ (2004). "Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.". J. Biol. Chem. 278 (52): 52524–30. doi:10.1074/jbc.M309343200. PMID 14570876.
Tisdale EJ, Kelly C, Artalejo CR (2005). "Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity.". J. Biol. Chem. 279 (52): 54046–52. doi:10.1074/jbc.M409472200. PMID 15485821.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Dong C, Wu G (2007). "Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.". Cell. Signal. 19 (11): 2388–99. doi:10.1016/j.cellsig.2007.07.017. PMID 17716866.