RAB1B

From Wikipedia, the free encyclopedia

RAB1B, member RAS oncogene family

PDB rendering based on 2fol.

Available structures: 2fol

Identifiers

Symbol(s)

RAB1B;

External IDs

MGI: 1923558 HomoloGene: 49926

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • GTP binding • transcription factor binding
Cellular Component:	• intracellular • Golgi apparatus • membrane
Biological Process:	• regulation of transcription, DNA-dependent • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001134089 (mRNA)
XP_001134089 (protein)

NM_029576 (mRNA)
NP_083852 (protein)

Location

Chr 11: 65.79 - 65.8 Mb

Chr 19: 5.1 - 5.11 Mb

Pubmed search

[1]

[2]

RAB1B, member RAS oncogene family, also known as RAB1B, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB1B RAB1B, member RAS oncogene family.

[edit] Further reading

Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.". J. Cell Biol. 115 (1): 31-43. PMID 1918138.
Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes.". J. Biol. Chem. 270 (43): 25541-8. PMID 7592724.
Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells.". Biochem. J. 318 ( Pt 3): 1007-14. PMID 8836150.
Chen D, Guo J, Gahl WA (1997). "RAB GTPases expressed in human melanoma cells.". Biochim. Biophys. Acta 1355 (1): 1-6. PMID 9030196.
Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein.". Mol. Biol. Cell 9 (1): 223-35. PMID 9437002.
Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes.". Int. J. Oncol. 15 (4): 727-36. PMID 10493955.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b.". EMBO Rep. 2 (4): 336-41. doi:10.1093/embo-reports/kve065. PMID 11306556.
Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins.". Biochem. Biophys. Res. Commun. 293 (3): 1060-5. doi:10.1016/S0006-291X(02)00326-1. PMID 12051767.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415-23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1.". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMID 15796781.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association.". Mol. Biol. Cell 18 (7): 2400-10. doi:10.1091/mbc.E06-11-1005. PMID 17429068.
Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation.". Science 318 (5852): 974-7. doi:10.1126/science.1149121. PMID 17947549.