RAB1A

From Wikipedia, the free encyclopedia

RAB1A, member RAS oncogene family

PDB rendering based on 2fol.

Available structures: 2fol

Identifiers

Symbol(s)

RAB1A; DKFZP564B163; RAB1

External IDs

OMIM: 179508 MGI: 97842 HomoloGene: 36154

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• endoplasmic reticulum • Golgi apparatus
Biological Process:	• ER to Golgi vesicle-mediated transport • small GTPase mediated signal transduction • protein transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004161 (mRNA)
NP_004152 (protein)

NM_008996 (mRNA)
NP_033022 (protein)

Location

Chr 2: 65.17 - 65.21 Mb

Chr 11: 20.1 - 20.13 Mb

Pubmed search

[1]

[2]

RAB1A, member RAS oncogene family, also known as RAB1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB1A RAB1A, member RAS oncogene family.

[edit] Further reading

Bailly E, McCaffrey M, Touchot N, et al. (1991). "Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.". Nature 350 (6320): 715–8. doi:10.1038/350715a0. PMID 1902553.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394–401. PMID 2501306.
Farnsworth CC, Seabra MC, Ericsson LH, et al. (1995). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 11963–7. PMID 7991565.
Cremers FP, Armstrong SA, Seabra MC, et al. (1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene.". J. Biol. Chem. 269 (3): 2111–7. PMID 8294464.
Karniguian A, Zahraoui A, Tavitian A (1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7647–51. PMID 8356066.
Wedemeyer N, Lengeling A, Ronsiek M, et al. (1997). "YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p.". Genomics 32 (3): 447–54. doi:10.1006/geno.1996.0140. PMID 8838809.
Martincic I, Peralta ME, Ngsee JK (1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor.". J. Biol. Chem. 272 (43): 26991–8. PMID 9341137.
Anant JS, Desnoyers L, Machius M, et al. (1999). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.". Biochemistry 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.
Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.". Horm. Metab. Res. 30 (11): 656–62. PMID 9918381.
Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion.". Science 289 (5478): 444–8. PMID 10903204.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Moyer BD, Allan BB, Balch WE (2001). "Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering.". Traffic 2 (4): 268–76. PMID 11285137.
Muslin AJ (2002). "Road Rage: Cardiac Rab1 and ER-to-Golgi Traffic.". Circ. Res. 89 (12): 1087–8. PMID 11739271.
Short B, Preisinger C, Körner R, et al. (2002). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMID 11739401.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Diao A, Rahman D, Pappin DJ, et al. (2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation.". J. Cell Biol. 160 (2): 201–12. doi:10.1083/jcb.200207045. PMID 12538640.
Satoh A, Wang Y, Malsam J, et al. (2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure.". Traffic 4 (3): 153–61. PMID 12656988.
Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins.". Biochem. Biophys. Res. Commun. 306 (1): 79–86. PMID 12788069.