RAB11A

From Wikipedia, the free encyclopedia

RAB11A, member RAS oncogene family

PDB rendering based on 1oiv.

Available structures: 1oiv, 1oiw, 1oix, 1yzk, 2d7c, 2f9l, 2f9m, 2gzd, 2gzh, 2hv8

Identifiers

Symbol(s)

RAB11A; MGC1490; YL8

External IDs

OMIM: 605570 MGI: 1858202 HomoloGene: 37903

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • transporter activity • protein binding • GTP binding • syntaxin binding
Cellular Component:	• trans-Golgi network
Biological Process:	• small GTPase mediated signal transduction • protein transport • plasma membrane to endosome transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004663 (mRNA)
NP_004654 (protein)

NM_017382 (mRNA)
NP_059078 (protein)

Location

Chr 15: 63.95 - 63.97 Mb

Chr 9: 64.51 - 64.54 Mb

Pubmed search

[1]

[2]

RAB11A, member RAS oncogene family, also known as RAB11A, is a human gene.

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.^[1]

[edit] References

^ Entrez Gene: RAB11A RAB11A, member RAS oncogene family.

[edit] Further reading

Drivas GT, Shih A, Coutavas EE, et al. (1991). "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.". Oncogene 6 (1): 3–9. PMID 1704119.
Sakurada K, Uchida K, Yamaguchi K, et al. (1991). "Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver.". Biochem. Biophys. Res. Commun. 177 (3): 1224–32. PMID 1711847.
Gromov PS, Celis JE, Hansen C, et al. (1998). "Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins.". FEBS Lett. 429 (3): 359–64. PMID 9662449.
Gromov P, Celis JE (1998). "Rab11a is modified in vivo by isoprenoid geranylgeranyl.". Electrophoresis 19 (10): 1803–7. doi:10.1002/elps.1150191043. PMID 9719562.
Zeng J, Ren M, Gravotta D, et al. (1999). "Identification of a putative effector protein for rab11 that participates in transferrin recycling.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2840–5. PMID 10077598.
Dumanchin C, Czech C, Campion D, et al. (1999). "Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport.". Hum. Mol. Genet. 8 (7): 1263–9. PMID 10369872.
Mammoto A, Ohtsuka T, Hotta I, et al. (1999). "Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling.". J. Biol. Chem. 274 (36): 25517–24. PMID 10464283.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.". Biochemistry 38 (36): 11711–21. PMID 10512627.
Prekeris R, Klumperman J, Scheller RH (2001). "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes.". Mol. Cell 6 (6): 1437–48. PMID 11163216.
Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems.". Mol. Biol. Cell 12 (6): 1843–57. PMID 11408590.
Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins.". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
Lindsay AJ, Hendrick AG, Cantalupo G, et al. (2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.". J. Biol. Chem. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
Lindsay AJ, McCaffrey MW (2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.". J. Biol. Chem. 277 (30): 27193–9. doi:10.1074/jbc.M200757200. PMID 11994279.
Scales SJ, Hesser BA, Masuda ES, Scheller RH (2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.". J. Biol. Chem. 277 (31): 28271–9. doi:10.1074/jbc.M204929200. PMID 12145319.
Band AM, Ali H, Vartiainen MK, et al. (2002). "Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton.". FEBS Lett. 531 (3): 513–9. PMID 12435603.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.". Biochem. Biophys. Res. Commun. 299 (5): 770–9. PMID 12470645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Roosterman D, Schmidlin F, Bunnett NW (2003). "Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.". Am. J. Physiol., Cell Physiol. 284 (5): C1319–29. doi:10.1152/ajpcell.00540.2002. PMID 12540381.
Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP.". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740.