R&B number-one hits of 1945 (USA)
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This list of R&B #1 hits of 1945 in the United States is part of the List of #1 R&B hits (USA).
| Issue Date | Song Title | Artist | Weeks at #1 |
| February 10 | Somebody’s Gotta Go | Cootie Williams and His Orchestra | 1 week |
| February 17 | I Wonder | Pvt. Cecil Gant | 2 weeks |
| February 24 | I Wonder | Roosevelt Sykes | 7 weeks |
| April 14 | Tippin' In | Erskine Hawkins and His Orchestra | 6 weeks* |
| April 21 | Mop! Mop! | Louis Jordan and His Tympany Five | 1 week |
| June 2 | Caldonia | Louis Jordan and His Tympany Five | 7 weeks |
| July 14 | Who Threw the Whiskey in the Well | Lucky Millinder and His Orchestra | 8 weeks |
| September 8 | The Honeydripper (Parts 1 & 2) | Joe Liggins and His Honeydrippers | 18 weeks |
An asterisk (*) after a song title means that the song lost and then regained the number-one spot.
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