Talk:Quinolone

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[edit] cleanup

I put a cleanup tag on this because it seems a bit all over the place. Compare with other antibiotic class articles. The adverse effects section could be a little more succinct, and a picture of the quinolone core ring system would be good. ben 14:04, 23 June 2006 (UTC)

This page [1] looks like it has some good source material for references...notes on the differences between the various generations would be good...too tired to go through it now...ben

The adverse reactions sections needs an update; as time goes on, I believe there are many more cases of tendon rupture complications than this article would indicate. The tendon ruptures either were not connected to the drug, or they have not been properly reported. Mare —Preceding unsigned comment added by 209.244.4.106 (talk) 17:01, 28 January 2008 (UTC)

[edit] ProQuin XR does not appear

ProQuin XR (Esprit Pharma) is a prolonged release ciprofloxacin, but it doesn't appear in this article. It is NOT equivalent to Cipro XR (Bayer Healthcare), which contains two forms of ciprofloxacin (see below).

ProQuin XR is actually pretty neat, expanding in the stomach over a number of hours.

From the ProQuin XR PI (http://www.proquinxr.com/pi/proquinxrpifull.pdf): "ProQuin XR (ciprofloxacin hydrochloride) extended-release tablets contain ciprofloxacin hydrochloride"

From the Cipro XR PI (http://www.ciproxr.com/HCP/pi.asp)  : "The tablets contain a combination of two types of ciprofloxacin drug substance, ciprofloxacin hydrochloride and ciprofloxacin betaine (base)."

[edit] insertion by Ananyo u

The following was inserted in the article on 10:59, 18 July 2006 by User:Ananyo u. I moved it here, because it was placed between the interwikilinks. May it's useful and should be inserted correctly in the article. Greetings --Saibo (Δ) 22:20, 18 July 2006 (UTC)

norfloxacin in combination with tinidazole or metronidazole is frequently used in veterinary medicine, specially in mixed enteric infection with bacteria and protozoa. the generic names are Normet susupension(norfloxacin with metronidazole), TiniNF suspension(tinidazole with norfloxacin)etc.

[edit] Resistance

I pulled the following text from the article:

Because of this serious problem the quinolones are generally not considered a first line agent but rather a drug of resort when therapy with other classes of antibiotics has failed or is inappropriate. It is hoped that judicious use of quinolone drugs may prolong the useful life of this group.

Jim Hoover, regional manager for state government affairs for the Bayer Corporation for the five northwest States, discussed the second and third generation quinolones. He states that "...Normally the quinolone class of drugs is used in patients who have failed at least one prior therapy. The patients tend to be fairly ill and require relatively acute care that often may be the last step before they are admitted into the hospital. …By the time the physicians get to this classification, they tend to have a good idea of what bacteria is involved, what antibiotic is the most potent for the bacteria and which penetrates that particular body side the best. …These drugs are often the last step before admission into the hospital..."[1]

Perhaps this is true in some parts of the world but FQs are very much the first-line agent in the United States, particularly in the emergency rooms (broad coverage and good bioavailability make it a "no thinking required" antibiotic). IDSA recommends it as a first-line agent for UTIs when TMP/SMX resistance is over 20% and treatment failure due to use of second-line agents cannot be tolerated, and levofloxacin has been approved for CAP. And let's not quote drug company spokespeople -- very little truth comes out of their mouths. - Emt147 Burninate! 05:36, 11 October 2006 (UTC)

[edit] Fact adjustments

A few notes:

1) Bacillus anthracis is not intracellular. If it were, it would not be susceptible to beta-lactam antibiotics (e.g., penicillin). A fluoroquinolone (ciprofloxacin) is an effective treatment for anthrax, however. It is the preferred means of treating inhalational anthrax.

2) Other intracellular bacteria include Mycoplasma pneumoniae and chlamydiae.

3) Peripheral neuropathy is not necessarily irreversible in quinolone exposure.

4) Rhabdomyolysis is not muscle wasting in the common sense of the term. Significant rhabdomyolysis most often occurs without evident wasting of the muscle.

5) Widespread use of fluoroquinolones in the developing world, particularly a population's unrestricted access to antibiotics, is also implicated in the rise of fluoroquinolone resistance.

I changed the text to fit these notes where it seemed appropriate.Dyslexic3 03:58, 6 December 2006 (UTC)

[edit] Generations of fluoroquinolones

According to the AAFP, gatifloxacin is 4th generation, not 3rd as suggested. Also the trade name Zymar refers to the ophthalmic solution and not to the po or iv. —The preceding unsigned comment was added by Sedmic (talk • contribs) 06:42, 15 January 2007 (UTC).

Please see http://www.aafp.org/afp/991201ap/tips/3.html . Ramin Herati (Sedmic) 06:42, 15 January 2007 (UTC)

[edit] topoisomerase 4 and 2

topo 2 is what humans have. topo 4 is what bacteria have. fluoroquinolones can affect both, but mainly topo 4- the target of interest. if these drugs greatly affected topo 2 we would be in trouble (there are drugs, like anthracyclines, targeting topo 2 and they are antineoplastic). for some reason i have noticed people editing the article to make topo 2 a target along with dna gyrase. this is incorrect. quinolones work by affecting mainly topo 4 (gram positive bacteria target) and dna gyrase (gram neg target). Brendan19 08:43, 14 May 2007 (UTC)

[edit] External links

External links on Wikipedia are supposed to be "encyclopedic in nature" and useful to a worldwide audience. Please read the external links policy (and perhaps the specific rules for medicine-related articles) before adding more external links.

The following kinds of links are inappropriate:

  • Online discussion groups or chat forums
  • Personal webpages and blogs
  • Multiple links to the same website
  • Fundraising events or groups
  • Websites that are recruiting for clinical trials
  • Websites that are selling things (e.g., books or memberships)

I realize that some links are helpful to certain users, but they still do not comply with Wikipedia policy, and therefore must not be included in the article. WhatamIdoing (talk) 07:11, 17 January 2008 (UTC)