Quinine 3-monooxygenase

From Wikipedia, the free encyclopedia

In enzymology, a quinine 3-monooxygenase (EC 1.14.13.67) is an enzyme that catalyzes the chemical reaction

quinine + NADPH + H⁺ + O₂ $\rightleftharpoons$ 3-hydroxyquinine + NADP⁺ + H₂O

The 4 substrates of this enzyme are quinine, NADPH, H⁺, and O₂, whereas its 3 products are 3-hydroxyquinine, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is quinine,NADPH:oxygen oxidoreductase. This enzyme is also called quinine 3-hydroxylase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1W0E, 1W0F, 1W0G, 2J0D, and 2V0M.

[edit] References

IUBMB entry for 1.14.13.67
BRENDA references for 1.14.13.67 (Recommended.)
PubMed references for 1.14.13.67
PubMed Central references for 1.14.13.67
Google Scholar references for 1.14.13.67
Relling MV, Evans R, Dass C, Desiderio DM, Nemec J (1992). "Human cytochrome P450 metabolism of teniposide and etoposide". J. Pharmacol. Exp. Ther. 261: 491–6. PMID 1578365.
S (1997). "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine". Br. J. Clin. Pharmacol. 43: 245–52. doi:10.1046/j.1365-2125.1997.00556.x. PMID 9088578.
Zhao XJ, Kawashiro T, Ishizaki T (1998). "Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways". Drug. Metab. Dispos. 26: 188–91. PMID 9456308.
Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T (1996). "Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450". J. Pharmacol. Exp. Ther. 279: 1327–34. PMID 8968357.