Quinate dehydrogenase (pyrroloquinoline-quinone)

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In enzymology, a quinate dehydrogenase (pyrroloquinoline-quinone) (EC 1.1.99.25) is an enzyme that catalyzes the chemical reaction

quinate + pyrroloquinoline-quinone $\rightleftharpoons$ 3-dehydroquinate + reduced pyrroloquinoline-quinone

Thus, the two substrates of this enzyme are quinate and pyrroloquinoline-quinone, whereas its two products are 3-dehydroquinate and reduced pyrroloquinoline-quinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is quinate:pyrroloquinoline-quinone 3-oxidoreductase. Other names in common use include NAD(P)+-independent quinate dehydrogenase, and quinate:pyrroloquinoline-quinone 5-oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

[edit] References

IUBMB entry for 1.1.99.25
BRENDA references for 1.1.99.25 (Recommended.)
PubMed references for 1.1.99.25
PubMed Central references for 1.1.99.25
Google Scholar references for 1.1.99.25
van Kleef MA, Duine JA (1988). "Bacterial NAD(P)-independent quinate dehydrogenase is a quinoprotein". Arch. Microbiol. 150: 32–6. doi:10.1007/BF00409714. PMID 3044290.
Adachi O, Tanasupawat S, Yoshihara N, Toyama H, Matsushita K (2003). "3-dehydroquinate production by oxidative fermentation and further conversion of 3-dehydroquinate to the intermediates in the shikimate pathway". Biosci. Biotechnol. Biochem. 67: 2124–31. doi:10.1271/bbb.67.2124. PMID 14586099.