Quinaldate 4-oxidoreductase

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In enzymology, a quinaldate 4-oxidoreductase (EC 1.3.99.18) is an enzyme that catalyzes the chemical reaction

quinaldate + acceptor + H₂O $\rightleftharpoons$ kynurenate + reduced acceptor

The 3 substrates of this enzyme are quinaldate, acceptor, and H₂O, whereas its two products are kynurenate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating). This enzyme is also called quinaldic acid 4-oxidoreductase.

[edit] References

IUBMB entry for 1.3.99.18
BRENDA references for 1.3.99.18 (Recommended.)
PubMed references for 1.3.99.18
PubMed Central references for 1.3.99.18
Google Scholar references for 1.3.99.18
Sauter M, Tshisuaka B, Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XX Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases". Biol. Chem. Hoppe. Seyler. 374: 1037–46. PMID 8292263.
Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XVIII Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1". Biol. Chem. Hoppe. Seyler. 374: 363–76. PMID 8357532.