Quaternium-15

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Quaternium-15
Identifiers
CAS number [4080-31-3]
PubChem 5475987
SMILES Cl\C=C/C[N+]23CN1CN(C3)CN(C2)C1.[Cl-]
Properties
Molecular formula C9H16Cl2N4
Molar mass 251.156 g/mol
Hazards
MSDS External MSDS
EU classification Harmful XN; Highly flammable F+
R-phrases R11 R22
S-phrases S16 S36
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances. It acts as a formaldehyde releaser. It can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.

It can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.

[edit] Safety concerns

Quaternium-15 is an allergen, and can cause contact dermatitis in susceptible individuals.[1] Many of those with an allergy to quaternium-15 are also allergic to formaldehyde. Allergic sensitivity to quaternium-15 can be detected using a patch test.[2] It is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases)[3]

[edit] References

  1. ^ Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. Australas J Dermatol. 2005 Nov;46(4):284-5. PMID 16197434
  2. ^ New Zealand Dermatological Society. Quaternium-15 contact allergy. DermNet NZ. Retrieved on 2007-05-31.
  3. ^ E. Warshaw, et al. Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. Journal of the American Academy of Dermatology, Volume 57, Issue 2, Pages 301-314

[edit] External links