QSOX1

From Wikipedia, the free encyclopedia

Quiescin Q6

Identifiers

QSCN6; Q6; QSOX1

External IDs

OMIM: 603120 MGI: 1330818 HomoloGene: 37690

Gene ontology
Molecular Function:	• molecular_function • electron carrier activity • protein disulfide oxidoreductase activity • thiol oxidase activity
Cellular Component:	• cellular_component • membrane • integral to membrane
Biological Process:	• regulation of progression through cell cycle • regulation of cell growth • negative regulation of cell proliferation • cell redox homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001004128 (mRNA)
NP_001004128 (protein)

NM_001024945 (mRNA)
NP_001020116 (protein)

Location

Chr 1: 178.39 - 178.44 Mb

Chr 1: 157.54 - 157.58 Mb

Pubmed search

[1]

[2]

Quiescin Q6, also known as QSCN6, is a human gene.^[1]

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: QSCN6 quiescin Q6.

[edit] Further reading

Thorpe C, Hoober KL, Raje S, et al. (2002). "Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes.". Arch. Biochem. Biophys. 405 (1): 1–12. PMID 12176051.
Coppock DL, Kopman C, Scandalis S, Gilleran S (1993). "Preferential gene expression in quiescent human lung fibroblasts.". Cell Growth Differ. 4 (6): 483–93. PMID 8396966.
Coppock DL, Cina-Poppe D, Gilleran S (1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1.". Genomics 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249.
Hoober KL, Glynn NM, Burnside J, et al. (1999). "Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases.". J. Biol. Chem. 274 (45): 31759–62. PMID 10542195.
Coppock D, Kopman C, Gudas J, Cina-Poppe DA (2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29.". Biochem. Biophys. Res. Commun. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID 10708601.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Radom J, Colin D, Thiebault F, et al. (2006). "Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain.". Biochim. Biophys. Acta 1759 (5): 225–33. doi:10.1016/j.bbaexp.2006.04.008. PMID 16806532.
Chakravarthi S, Jessop CE, Willer M, et al. (2007). "Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1.". Biochem. J. 404 (3): 403–11. doi:10.1042/BJ20061510. PMID 17331072.
Jaje J, Wolcott HN, Fadugba O, et al.. "A flavin-dependent sulfhydryl oxidase in bovine milk.". Biochemistry 46 (45): 13031–40. doi:10.1021/bi7016975. PMID 17944490.