QKI

From Wikipedia, the free encyclopedia

Quaking homolog, KH domain RNA binding (mouse)

PDB rendering based on 2bl5.

Available structures: 2bl5

Identifiers

Symbol(s)

QKI; DKFZp586I0923; Hqk; QK; QK3

External IDs

OMIM: 609590 MGI: 97837 HomoloGene: 11059

Gene ontology
Molecular Function:	• RNA binding
Cellular Component:	• nucleus
Biological Process:	• vasculogenesis • mRNA processing • regulation of translation • transport • multicellular organismal development • spermatogenesis • RNA splicing • myelination • muscle cell differentiation • long-chain fatty acid biosynthetic process • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_945803 (mRNA)
XP_950896 (protein)

XM_985305 (mRNA)
XP_990399 (protein)

Location

Chr 6: 163.76 - 163.91 Mb

Chr 17: 10.05 - 10.16 Mb

Pubmed search

[1]

[2]

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a human gene.^[1]

QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse).

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Saccomanno L, Loushin C, Jan E, et al. (1999). "The STAR protein QKI-6 is a translational repressor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. PMID 10535969.
Li ZZ, Kondo T, Murata T, et al. (2002). "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.". Jpn. J. Cancer Res. 93 (2): 167–77. PMID 11856480.
Wu JI, Reed RB, Grabowski PJ, Artzt K (2002). "Function of quaking in myelination: regulation of alternative splicing.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4233–8. doi:10.1073/pnas.072090399. PMID 11917126.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Moore FL, Jaruzelska J, Fox MS, et al. (2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 538–43. doi:10.1073/pnas.0234478100. PMID 12511597.
Côté J, Boisvert FM, Boulanger MC, et al. (2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.". Mol. Biol. Cell 14 (1): 274–87. doi:10.1091/mbc.E02-08-0484. PMID 12529443.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ichimura K, Mungall AJ, Fiegler H, et al. (2006). "Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH.". Oncogene 25 (8): 1261–71. doi:10.1038/sj.onc.1209156. PMID 16205629.
Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90. doi:10.1002/ajmg.b.30243. PMID 16342280.
Aberg K, Saetre P, Jareborg N, Jazin E (2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. doi:10.1073/pnas.0601213103. PMID 16641098.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia.". The American journal of psychiatry 163 (10): 1834–7. doi:10.1176/appi.ajp.163.10.1834. PMID 17012699.
Zhao L, Tian D, Xia M, et al. (2006). "Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.". J. Neurosci. 26 (44): 11278–86. doi:10.1523/JNEUROSCI.2677-06.2006. PMID 17079655.