Talk:Pyruvate decarboxylase
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I have added the chemical reaction stub but to be honest, I can barely recognise this article as written in English. I think it needs a little dumbing down as anyone who can make sense as it stands probably doesn't need to look it up. L-Bit 01:41, 24 October 2005 (UTC)
[edit] Merge
Bit of a nomenclature issue here. Both PDC and PHD claim to be E1 of the pyruvate dehydrogenase complex. We should merge these pages. Isopropyl (talk) 21:15, 9 May 2008 (UTC)
Merging these would lead to confusion:This is a nomenclature problem: PDC is used also to refer to the enzyme that takes pyruvate and converts it to acetaldehydge.
In yeast, the pyruvate decarboxylase that is used to make acetaldehyde on the way to ethanol is a separate gene from the E1 enzyme in the pyruvate dehydrogenase complex.(PDC1, yeast chromsome 12, vs PDA1, yeast chromosome 5).
Referring to E1 of the PDH as "a" pyruvate decarboxylase is perhaps a more accurate description of the actual reaction per se. Referring to E1 as the dehydrogenease is actually referring to more what the complex is called.
None of the textbooks I looked through mentioned identity of the enzymes of (including Stryer, Voet, Boyer, etc.)claim the two reactions are catalyzed by the same enzyme. (HJD)
To clarify the two enzymes are different, [1] pyruvate decarboxylase is not present in animals. It is the enzyme that catalyses the first of the two reactions that ultimately produce ethanol. For these reasons the two articles shoud not be merged. —Preceding unsigned comment added by Lisa256B (talk • contribs) 09:33, 3 June 2008 (UTC)
