Pyruvate oxidase (CoA-acetylating)

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In enzymology, a pyruvate oxidase (CoA-acetylating) (EC 1.2.3.6) is an enzyme that catalyzes the chemical reaction

pyruvate + CoA + O₂ acetyl-CoA + CO₂ + H₂O₂

The 3 substrates of this enzyme are pyruvate, CoA, and O₂, whereas its 3 products are acetyl-CoA, CO₂, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2-oxidoreductase (CoA-acetylating). This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.2.3.6
• BRENDA references for 1.2.3.6 (Recommended.)
• PubMed references for 1.2.3.6
• PubMed Central references for 1.2.3.6
• Google Scholar references for 1.2.3.6
• Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252: 726–31. PMID 13076. 
• Takeuchi T, Weinbach EC, Diamond LS (1975). "Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica". Biochem. Biophys. Res. Commun. 65: 591–6. PMID 167776. 

[edit] External links

The CAS registry number for this enzyme class is 62213-57-4.

• IUBMB entry for 1.2.3.6

• KEGG entry for 1.2.3.6

• BRENDA entry for 1.2.3.6

• NiceZyme view of 1.2.3.6

• EC2PDB: PDB structures for 1.2.3.6

• PRIAM entry for 1.2.3.6

• PUMA2 entry for 1.2.3.6

• IntEnz: Integrated Enzyme entry for 1.2.3.6

• MetaCyc entry for 1.2.3.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050244: pyruvate oxidase (CoA-acetylating)

• AMIGO entry for GO code 0050244: pyruvate oxidase (CoA-acetylating)