Pyrroline-2-carboxylate reductase

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In enzymology, a pyrroline-2-carboxylate reductase (EC 1.5.1.1) is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+ 1-pyrroline-2-carboxylate + NAD(P)H + H⁺

The 3 substrates of this enzyme are L-proline, NAD⁺, and NADP⁺, whereas its 4 products are 1-pyrroline-2-carboxylate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 2-oxidoreductase. This enzyme is also called Delta1-pyrroline-2-carboxylate reductase. This enzyme participates in lysine degradation and arginine and proline metabolism.

[edit] References

• IUBMB entry for 1.5.1.1
• BRENDA references for 1.5.1.1 (Recommended.)
• PubMed references for 1.5.1.1
• PubMed Central references for 1.5.1.1
• Google Scholar references for 1.5.1.1
• Meister A, Radhakrishnan AN and Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229: 789–800. 

[edit] External links

The CAS registry number for this enzyme class is 9029-16-7.

• IUBMB entry for 1.5.1.1

• KEGG entry for 1.5.1.1

• BRENDA entry for 1.5.1.1

• NiceZyme view of 1.5.1.1

• EC2PDB: PDB structures for 1.5.1.1

• PRIAM entry for 1.5.1.1

• PUMA2 entry for 1.5.1.1

• IntEnz: Integrated Enzyme entry for 1.5.1.1

• MetaCyc entry for 1.5.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050241: pyrroline-2-carboxylate reductase

• AMIGO entry for GO code 0050241: pyrroline-2-carboxylate reductase