Pyrithiamine deaminase

From Wikipedia, the free encyclopedia

In enzymology, a pyrithiamine deaminase (EC 3.5.4.20) is an enzyme that catalyzes the chemical reaction

1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2- methylpyridinium bromide + H₂O 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2- methylpyridinium bromide + NH₃

The 3 substrates of this enzyme are 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-, methylpyridinium bromide, and H₂O, whereas its 3 products are 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-, methylpyridinium bromide, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methy lpyridinium-bromide aminohydrolase.

[edit] References

• IUBMB entry for 3.5.4.20
• BRENDA references for 3.5.4.20 (Recommended.)
• PubMed references for 3.5.4.20
• PubMed Central references for 3.5.4.20
• Google Scholar references for 3.5.4.20
• Sinha AK, Chatterjee GC (1968). "Metabolism of pyrithiamine by the pyrithiamine-requiring mutant of Staphylococcus aureus". Biochem. J. 107: 165–9. PMID 5641872. 

[edit] External links

The CAS registry number for this enzyme class is 37289-23-9.

• IUBMB entry for 3.5.4.20

• KEGG entry for 3.5.4.20

• BRENDA entry for 3.5.4.20

• NiceZyme view of 3.5.4.20

• EC2PDB: PDB structures for 3.5.4.20

• PRIAM entry for 3.5.4.20

• PUMA2 entry for 3.5.4.20

• IntEnz: Integrated Enzyme entry for 3.5.4.20

• MetaCyc entry for 3.5.4.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050239: pyrithiamine deaminase

• AMIGO entry for GO code 0050239: pyrithiamine deaminase