Pyrimidodiazepine synthase

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In enzymology, a pyrimidodiazepine synthase (EC 1.5.4.1) is an enzyme that catalyzes the chemical reaction

a pyrimidodiazepine + glutathione disulfide + H₂O 6-pyruvoyltetrahydropterin + 2 glutathione

The 3 substrates of this enzyme are pyrimidodiazepine, glutathione disulfide, and H₂O, whereas its two products are 6-pyruvoyltetrahydropterin and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a disulfide as acceptor. The systematic name of this enzyme class is pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Other names in common use include PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening,, and cyclizing). This enzyme participates in glutathione metabolism.

[edit] References

• IUBMB entry for 1.5.4.1
• BRENDA references for 1.5.4.1 (Recommended.)
• PubMed references for 1.5.4.1
• PubMed Central references for 1.5.4.1
• Google Scholar references for 1.5.4.1
• Wiederrecht GJ, Brown GM (1984). "Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins". J. Biol. Chem. 259: 14121–7. PMID 6438092. 

[edit] External links

The CAS registry number for this enzyme class is 93586-06-2.

• IUBMB entry for 1.5.4.1

• KEGG entry for 1.5.4.1

• BRENDA entry for 1.5.4.1

• NiceZyme view of 1.5.4.1

• EC2PDB: PDB structures for 1.5.4.1

• PRIAM entry for 1.5.4.1

• PUMA2 entry for 1.5.4.1

• IntEnz: Integrated Enzyme entry for 1.5.4.1

• MetaCyc entry for 1.5.4.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004734: pyrimidodiazepine synthase

• AMIGO entry for GO code 0004734: pyrimidodiazepine synthase