Pyrimidine-deoxynucleoside 1'-dioxygenase

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In enzymology, a pyrimidine-deoxynucleoside 1'-dioxygenase (EC 1.14.11.10) is an enzyme that catalyzes the chemical reaction

2'-deoxyuridine + 2-oxoglutarate + O₂ uracil + 2-deoxyribonolactone + succinate + CO₂

The 3 substrates of this enzyme are 2'-deoxyuridine, 2-oxoglutarate, and O₂, whereas its 4 products are uracil, 2-deoxyribonolactone, succinate, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating). This enzyme is also called deoxyuridine-uridine 1'-dioxygenase. It has 2 cofactors: iron, and Ascorbate.

[edit] References

• IUBMB entry for 1.14.11.10
• BRENDA references for 1.14.11.10 (Recommended.)
• PubMed references for 1.14.11.10
• PubMed Central references for 1.14.11.10
• Google Scholar references for 1.14.11.10
• Stubbe J (1985). "Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation". J. Biol. Chem. 260: 9972–5. PMID 4040518. 

[edit] External links

The CAS registry number for this enzyme class is 98865-52-2.

• IUBMB entry for 1.14.11.10

• KEGG entry for 1.14.11.10

• BRENDA entry for 1.14.11.10

• NiceZyme view of 1.14.11.10

• EC2PDB: PDB structures for 1.14.11.10

• PRIAM entry for 1.14.11.10

• PUMA2 entry for 1.14.11.10

• IntEnz: Integrated Enzyme entry for 1.14.11.10

• MetaCyc entry for 1.14.11.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047079: pyrimidine-deoxynucleoside 1'-dioxygenase

• AMIGO entry for GO code 0047079: pyrimidine-deoxynucleoside 1'-dioxygenase