Pyridoxine 5-dehydrogenase

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In enzymology, a pyridoxine 5-dehydrogenase (EC 1.1.99.9) is an enzyme that catalyzes the chemical reaction

pyridoxine + acceptor isopyridoxal + reduced acceptor

Thus, the two substrates of this enzyme are pyridoxine and acceptor, whereas its two products are isopyridoxal and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is pyridoxine:acceptor 5-oxidoreductase. Other names in common use include pyridoxal-5-dehydrogenase, pyridoxol 5-dehydrogenase, pyridoxin 5-dehydrogenase, pyridoxine dehydrogenase, pyridoxine 5'-dehydrogenase, and pyridoxine:(acceptor) 5-oxidoreductase. This enzyme participates in vitamin b6 metabolism. It has 2 cofactors: FAD, and PQQ.

[edit] References

• IUBMB entry for 1.1.99.9
• BRENDA references for 1.1.99.9 (Recommended.)
• PubMed references for 1.1.99.9
• PubMed Central references for 1.1.99.9
• Google Scholar references for 1.1.99.9
• Sundaram TK, Snell EE (1969). "The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine". J. Biol. Chem. 244: 2577–84. PMID 5769992. 

[edit] External links

The CAS registry number for this enzyme class is 9023-39-6.

• IUBMB entry for 1.1.99.9

• KEGG entry for 1.1.99.9

• BRENDA entry for 1.1.99.9

• NiceZyme view of 1.1.99.9

• EC2PDB: PDB structures for 1.1.99.9

• PRIAM entry for 1.1.99.9

• PUMA2 entry for 1.1.99.9

• IntEnz: Integrated Enzyme entry for 1.1.99.9

• MetaCyc entry for 1.1.99.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050238: pyridoxine 5-dehydrogenase

• AMIGO entry for GO code 0050238: pyridoxine 5-dehydrogenase