Pyrazolylalanine synthase

From Wikipedia, the free encyclopedia

In enzymology, a pyrazolylalanine synthase (EC 4.2.1.50) is an enzyme that catalyzes the chemical reaction

L-serine + pyrazole 3-(pyrazol-1-yl)-L-alanine + H₂O

Thus, the two substrates of this enzyme are L-serine and pyrazole, whereas its two products are 3-(pyrazol-1-yl)-L-alanine and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is L-serine hydro-lyase [adding pyrazole 3-(pyrazol-1-yl)-L-alanine-forming]. Other names in common use include beta-pyrazolylalaninase, beta-(1-pyrazolyl)alanine synthase, and L-serine hydro-lyase (adding pyrazole). It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.2.1.50
• BRENDA references for 4.2.1.50 (Recommended.)
• PubMed references for 4.2.1.50
• PubMed Central references for 4.2.1.50
• Google Scholar references for 4.2.1.50
• Dunnill PM and Fowden L (1963). "The biosynthesis of beta-pyrazol-1-ylalanine". J. Exp. Bot. 14: 237–248. 

[edit] External links

The CAS registry number for this enzyme class is 37290-81-6.

• IUBMB entry for 4.2.1.50

• KEGG entry for 4.2.1.50

• BRENDA entry for 4.2.1.50

• NiceZyme view of 4.2.1.50

• EC2PDB: PDB structures for 4.2.1.50

• PRIAM entry for 4.2.1.50

• PUMA2 entry for 4.2.1.50

• IntEnz: Integrated Enzyme entry for 4.2.1.50

• MetaCyc entry for 4.2.1.50

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050234: pyrazolylalanine synthase

• AMIGO entry for GO code 0050234: pyrazolylalanine synthase