Pyrazole
From Wikipedia, the free encyclopedia
| Pyrazole | |
|---|---|
 |
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| IUPAC name | Pyrazole |
| Other names | 1,2-diazole |
| Identifiers | |
| CAS number | [288-13-1] |
| SMILES | C1=CC=NN1 |
| Properties | |
| Molecular formula | C3H4N2 |
| Molar mass | 68.07 g/mol |
| Melting point |
66-70 °C |
| Boiling point |
168-188 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Pyrazole refers both to the class of simple aromatic ring organic compounds of the heterocyclic series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions and to the unsubstituted parent compound. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature.
[edit] Pyrazoles
Pyrazoles are produced synthetically through the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation.
In medicine, pyrazoles are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.
Pyrazoles react with potassium borohydride to form a class of ligands known as Scorpionates.
Structurally related compounds are pyrazoline and pyrazolidine.
[edit] See also
- Benzimidazole, an imidazole analog with a fused benzene ring.
- Pyrrole, an analog with only one nitrogen atom in position 1.
- Oxazole, an analog with the nitrogen atom in position 1 replaced by oxygen.
- Imidazole, an analog with two non-adjacent nitrogen atoms.
- Simple aromatic rings
- Phenylbutazone,Pyrazolone, pyrazolidinedione, 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione.
