PYGO2

From Wikipedia, the free encyclopedia

Pygopus homolog 2 (Drosophila)

Identifiers

PYGO2; 1190004M21Rik; FLJ33226

External IDs

OMIM: 606903 MGI: 1916161 HomoloGene: 44519

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • Wnt receptor signaling pathway

Orthologs

Human

Mouse

n/a

Refseq

NM_138300 (mRNA)
NP_612157 (protein)

XM_001003051 (mRNA)
XP_001003051 (protein)

Location

Chr 1: 153.2 - 153.2 Mb

Chr 3: 89.52 - 89.52 Mb

Pubmed search

[1]

[2]

Pygopus homolog 2 (Drosophila), also known as PYGO2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila).

[edit] Further reading

Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.". Cell 109 (1): 47-60. PMID 11955446.
Thompson B, Townsley F, Rosin-Arbesfeld R, et al. (2002). "A new nuclear component of the Wnt signalling pathway.". Nat. Cell Biol. 4 (5): 367-73. doi:10.1038/ncb786. PMID 11988739.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development.". J. Biol. Chem. 279 (7): 5177-83. doi:10.1074/jbc.M309722200. PMID 14612447.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874.
Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer.". Clin. Cancer Res. 12 (7 Pt 1): 2216-23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.". Mech. Dev. 124 (1): 59-67. doi:10.1016/j.mod.2006.09.006. PMID 17113272.
Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer.". Int. J. Oncol. 30 (2): 357-63. PMID 17203217.