From Wikipedia, the free encyclopedia
| Purine riboswitch |
 |
| Type: |
Cis-reg; riboswitch; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Boese B, Barrick JE |
| Avg length: |
102.1 nucleotides |
| Avg identity: |
56% |
|
Purine riboswitches are RNA structures that regulate protein biosynthesis in response to purines[1]. In general, riboswitches are metabolite-binding domains within certain messenger RNAs that act as precision sensors for their corresponding targets. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression.[2]
Purine riboswitches are a class of riboswitches that selectively recognises guanine and become saturated at concentrations as low as 5 nM. In Bacillus subtilis, this mRNA motif is located on at least five separate transcriptional units that together encode 17 genes that are mostly involved in purine transport and purine nucleotide synthesis.[1] As some members of this family are also specific for adenine[3] or deoxyguanosine[4], this family are termed purine riboswitches.
[edit] References
- ^ a b Mandal, M; Boese B, Barrick JE, Winkler WC, Breaker RR (2003). "Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria". Cell 113: 577–586. doi:10.1016/S0092-8674(03)00391-X. PMID 12787499.
- ^ Batey, RT; Gilbert SD, Montange RK (2004). "Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine". Nature. 432: 411–415. doi:10.1038/nature03037. PMID 15549109.
- ^ Mandal, M; Breaker RR (2004). "Adenine riboswitches and gene activation by disruption of a transcription terminator". Nat Struct Mol Biol 11: 29–35. doi:10.1038/nsmb710. PMID 14718920.
- ^ Kim JN, Roth A, Breaker RR (2007). "Guanine riboswitch variants from Mesoplasma florum selectively recognize 2'-deoxyguanosine". Proc. Natl. Acad. Sci. U.S.A. 104 (41): 16092–7. doi:10.1073/pnas.0705884104. PMID 17911257.
[edit] External links
