Purine imidazole-ring cyclase

From Wikipedia, the free encyclopedia

In enzymology, a purine imidazole-ring cyclase (EC 4.3.2.4) is an enzyme that catalyzes the chemical reaction

DNA 4,6-diamino-5-formamidopyrimidine DNA adenine + H₂O

Hence, this enzyme has one substrate, DNA 4,6-diamino-5-formamidopyrimidine, and two products, DNA adenine and H₂O.

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming).

[edit] References

• IUBMB entry for 4.3.2.4
• BRENDA references for 4.3.2.4 (Recommended.)
• PubMed references for 4.3.2.4
• PubMed Central references for 4.3.2.4
• Google Scholar references for 4.3.2.4
• Chetsanga CJ, Grigorian C (1985). "In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiation". Proc. Natl. Acad. Sci. U. S. A. 82: 633–7. doi:10.1073/pnas.82.3.633. PMID 3856219. 

[edit] External links

The CAS registry number for this enzyme class is 95990-28-6.

• IUBMB entry for 4.3.2.4

• KEGG entry for 4.3.2.4

• BRENDA entry for 4.3.2.4

• NiceZyme view of 4.3.2.4

• EC2PDB: PDB structures for 4.3.2.4

• PRIAM entry for 4.3.2.4

• PUMA2 entry for 4.3.2.4

• IntEnz: Integrated Enzyme entry for 4.3.2.4

• MetaCyc entry for 4.3.2.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050230: purine imidazole-ring cyclase

• AMIGO entry for GO code 0050230: purine imidazole-ring cyclase